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| CYP11B2基因-344T/C多态性与高血压血瘀证的相关性研究 | |
| 引用本文： | 魏世超,骆杰伟,陈慧,吴小盈,林慧中,陈燕,李德育,庄文锦.CYP11B2基因-344T/C多态性与高血压血瘀证的相关性研究[J].光明中医,2009,24(10):1831-1834. |
| 作者姓名： | 魏世超 骆杰伟 陈慧 吴小盈 林慧中 陈燕 李德育 庄文锦 |
| 作者单位： | 1. 福建省立医院,福州,350001 2. 福建省立医院,福州,350001;福建医科大学省立临床学院,福州,350001 3. 福建协和医院,福州,350001 4. 厦门市中山医院,厦门,361004 |
| 基金项目： | 福建省自然科学基金资助项目，福建省青年科技人才创新项目 |
| 摘 要： | 目的:探讨醛固酮合成酶(CYP11B2)基因-344T/C多态性与高血压病血瘀证(EH-BSS)的关系.方法:收集高血压病血瘀证(EH-BSS)患者532例,高血压病非血瘀证298组(EH-non-BSS),血压正常对照者512例(Control),抽外周静脉血提取DNA,采用聚合酶链反应-限制性内切酶片段长度多态性(PCR-RFLP)检测CYP11B2基因-344T/C多态性类型.结果:卡方分割后重度EH-BSS组的TC+CC频率(55.23%)高于轻度EH-BSS组(46.83%)、EH-non-BSS组(45.30%)、Control组(43.16%),有统计学意义(X2=7.489,P=0.006).多因素Logistic回归调整混杂因素后,以EH-non-BSS组为参照系,CYP11B2-TC/CC型患重度EH-BSS的的相对危险度(OR值)为1.589(95%CI:1.035-2.440,P=0.034).结论:携带有CYP11B2-TC/CC基因型可能是重度EH-BSS易患因素之一. |
| 关 键 词： | 基因多态性 高血压 血瘀证 醛固酮合成酶 |
Relation Between-344T/C Polymorphisms of CYP11B2 Gene and Essential Hypertension with Blood Stasis Syndrome of TCM |
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| Wei Shichao Luo Jiewei Chen Hui.Relation Between-344T/C Polymorphisms of CYP11B2 Gene and Essential Hypertension with Blood Stasis Syndrome of TCM[J].Journal of Traditional Chinese Medicine,2009,24(10):1831-1834. | |
| Authors: | Wei Shichao Luo Jiewei Chen Hui |
| Institution: | Wei Shichao Luo Jiewei Chen Hui (Fujian Provincial Hospital 350001) |
| Abstract: | Objectives:to examine relationship between the-344T/C polymorphisms of CYP11B2 gene and Essential Hypertension(EH) with blood stasis syndrome(BSS) of Traditional Chinese Medicine.Methods:The study cohort recruited 830 persons with EH and 512 normotensive controls in South Han Chinese,including 532 subjects of BSS(EH-BSS group) which made up of 331 subjects with low-grade BSS(I(-BSS) and 201 severe BSS subjects(II(-BSS),298 subjects of no BSS(EH-non-BSS group) by TCM classification.All the subjects were geno... |
| Keywords: | Polymorphism Genetic Hypertension blood stasis Aldosterone Synthase |
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