急性冠状动脉综合征患者妊娠相关血浆蛋白A的变化

目的:观察急性冠状动脉综合征(ACS)患者妊娠相关血浆蛋白A(PAPP-A) 水平的变化.方法:冠状动脉造影(CAG)证实的冠心病患者80例,分为ACS组(53例) 、稳定型心绞痛(SA)组(27例),以23例CAG正常者为正常对照组;测定各组患者入院时外周血清PAPP-A水平, 分析不同组别间及ACS组、SA组中冠状动脉病变不同程度者PAPP-A水平的变化,并分析PAPP-A水平与TnT、CK-MB的相关性.结果:①ACS组的PAPP-A水平显著高于正常对照组和SA组(P＜0.01),正常对照组与SA组之间及ACS组中不稳定型心绞痛和急性心肌梗死亚组PAPP-A水平比较差异均无统计学意义(P＞0.05);②PAPP-A水平与CK-MB、TnT水平无显著相关;③ACS组、SA组中冠状动脉病变不同程度亚组PAPP-A水平比较差异均无统计学意义(P＞0.05).结论:检测PAPP-A水平对ACS早期诊断可能有一定的意义,但冠状动脉病变程度与PAPP-A水平无显著相关.

Change of pregnancy associated plasma protein-A levels in patients with acute coronary syndrome

Objective:To observe the changes of PAPP-A level of different clinical spectra patients with coronary artery disease(CAD) .Method:Eighty patients with CAD diagnosed by coronary angiography(CAG), including 27 cases with stable pectoris(SA), 31 cases with unstable pectoris(UA) and 22 cases with acute myocardial infarction(AMI) and 23 non-CAD cases were studied. The patients are also divided single, double and three-vessel lesion groups and reckoned corresponding to Jenkin`s scores which reflect the degree of pathological changes;The blood serum of all objects were collected on admission for measure of PAPP-A, CK-MB and TnT. The PAPP-A levels among different groups was analyzed and compared. So were the PAPP-A levels of AMI and UA group is significantly higher than that of SA and NON-CAD group (P<0.01), while there is no significant difference no significant difference of the PAPP-A level among the different extent of coronary pathological change in CAD patients(P>0.05).Conclusion:The PAPP-A level may be a biomarker of early diagnosis for ACS patients, though there is no correlation between the degree of pathological change and the PAPP-A level.