利福昔明干混悬剂溶出度测定方法研究

目的：建立利福昔明干混悬剂溶出度的测定方法。方法：采用桨法,以900mL 0.25%十二烷基硫酸钠溶液为溶出介质,转速为50r/min,45min时取样,用紫外分光光度法在454nm波长处测定利福昔明干混悬剂的溶出量,溶出限度为标示量的70%。结果：利福昔明溶液在5.182～51.819μg/mL浓度范围内呈良好的线性关系,r=0.999 8（n=6）;平均回收率为100.84%,RSD为0.61%（n=9）。结论：该方法简便、准确、重现性好,可用于利福昔明的质量控制。

Research on Dissolution Test Method of Rifaximin Dry Suspension

Objective：To establish the determination method for the dissolution rate of Rifaximin Dry Suspension.Methods：The second method for dissolution test was used with 0.25% sodium dodecyl sulfate as the dissolution medium and the rotation speed was 50r/min,after 45 min sampling,UV spectrophotometry was adopted to measure the dissolved amount of Rifaximin dry suspension at the wavelength of 454nm.The dissolution-n limit was 70% of the labeled amount.Results：The linear range of baicalin was 5.182~51.819μg/mL（r=0.999 8）with an average recovery of 100.84%（RSD=0.61%,n=9）.Conclusion：The method is sensitive,accurate and rapid for the quality control of Rifaximin dry suspension.