牙周基础治疗联合替硝唑胶囊治疗糖尿病性牙周炎的效果分析

目的 探讨牙周基础治疗联合替硝唑胶囊治疗糖尿病性牙周炎的效果及安全性.方法 选取2011年12月至2013年3月北京军区总医院门诊糖尿病性牙周炎患者60例,完全随机分为观察组、对照组,各30例.观察组给予牙周基础治疗和糖尿病常规治疗,同时口服替硝唑胶囊1.0 g/次,1次/d,疗程6d;对照组给予牙周基础治疗和糖尿病常规治疗.治疗后第2、8周复查牙龈指数、改良龈沟出血指数(BI)、牙周袋深度(PD)、附着丧失、糖化血红蛋白(HbA1c).结果 治疗后第8周,观察组和对照组牙龈指数、BI、PD、附着丧失比较,差异有统计学意义[分别为:(0.9±0.3)分比(1.6±0.4)分、(0.9±0.3)分比(1.3±0.5)分、(2.5±0.5)mm比(3.0±0.5)mm、(1.6±0.4)mm比(2.2±0.6) mm,P＜0.05];2组患者治疗后第8周HbA1c分别与本组治疗前比较,差异无统计学意义(P＞0.05),2组患者治疗后HbA1c比较,差异无统计学意义(P＞0.05).治疗后,观察组总有效率100.0％(30/30)高于对照组86.7％(26/30),差异有统计学意义(P＜0.05).结论 牙周基础治疗联合替硝唑胶囊治疗能加速局部炎症消退,增加牙周附着水平,有效改善患牙周各项指标.

Analysis of curative effect of periodontal initial therapy combined with tinidazole capsules in treatment of di- abetic periodontltis

Objective To discuss the therapeutic effect and safety of periodontal initial therapy combined with tinidazole capsules in treatment of diabetic periodontitis and diabetes mellitus. Methods Sixty outpatients of diabetic periodontitis, were randomly divided into observation group and control group 30 cases each. Observation group was given conventional periodontal basic treatment and diabetes treatment, at the same time taking tinidazole capsules; the controX group was given conventional periodontal basic treatment and diabetes treatment, periodontal index, bleeding index （BI） of project and glycosylated hemoglobin（HbAlc） after 2 weeks, 8 weeks treatment were cheeked. Results After 8 weeks treatment, observation group and control group with gingivalindex（GI）, BI, pro- bing depth （ PD ）, attachmentloss （AL） indexes were compared [ respectively （ 0. 9 ＋ 0. 3 ） scores vs （ 1. 6 ~ 0.4）scores,（0.9 ＋0.3）scores vs（1.3 ＋0.5）scores, （2.5 ＋0.5）ram vs （3.0 ＋0.5）ram, （1.6 ＋0.4）ram vs （2.2 ~ 0.6） mm ], the difference was statistically significant （ P 〈 0.05 ）. 8 weeks after treatment of HbA1 c chan- ges, compared with control group, the change of periodontal watch without statistical significance（P 〉 0.05）. After treatment, the total effective rate of observation group was 100.0% （30/30）, which was higher than the rate of con- trol group [ 86.7% （26/30）], the difference was statistically significant（P 〈0.05 ）. Conclusion The treatment of periodontal initial therapy combined with tinidazole capsules can accelerate the local inflammation subsided, in- crease the level of periodontal attachment and strengthen the therapeutic effect of diabetic periodontitis.