克罗恩病患者焦虑抑郁状况及其影响因素分析

目的 分析克罗恩病（Crohn’s disease, CD）患者的焦虑和抑郁状况、相关影响因素及其对患者健康生命质量的影响。方法 选择2021年2月至2022年2月就诊于复旦大学附属中山医院的CD患者共100例，采集其人口学资料及疾病相关信息。研究对象填写焦虑自评量表(SAS)、抑郁自评量表（SDS）、患者报告结局（PRO）、炎症性肠病患者生活质量问卷（IBDQ）和慢性病治疗功能评估-疲劳量表（FACIT-F）。采用卡方检验和logistic回归分析焦虑、抑郁相关影响因素；采用独立样本t检验分析焦虑、抑郁对IBDQ和FACIT-F评分的影响。结果 CD患者合并焦虑、抑郁的比例明显高于健康对照组（焦虑：58.0%vs 9.4%,P<0.001；抑郁：43.0%vs 11.8%,P<0.001）,SAS和SDS评分升高。患者为女性、具有肠外表现、疾病处于活动期（PRO2=1）为焦虑危险因素（P<0.05）；文化程度较高和疾病处于活动期（PRO2=1）是抑郁危险因素（P<0.05）。具有焦虑和抑郁情绪患者的IBDQ和FACIT-F评分明显降低（P<0.05）。结...

Risk factors of anxiety and depression in patients with Crohn's disease

Objective To analyze the psychological symptoms in patients with Crohn''s disease, and to investigate the risk factors of anxiety and depression and its effect on health-related quality of life. Methods A total of 100 patients with Crohn''s disease from Feb. 2021 to Feb. 2022 in Zhongshan Hospital, Fudan University were recruited. Demographics and disease characteristic informations of patients were collected. Self-rating anxiety scale (SAS), self-rating depression scale (SDS), a two-item patient-reported outcome (PRO2), inflammatory bowel disease quality of life questionnaire (IBDQ), and the functional assessment of chronic illness therapy-fatigue (FACIT-F) scale were used to estimate the psychological condition and quality of life of patients. Chi-square test and logistic regression were used to analyze the influencing factors of anxiety and depression, and independent sample t test was used to analyze the effect of anxiety and depression on IBDQ and FACIT-F scores in patients. Results The incidences of anxiety and depression in CD patients were significantly higher than healthy controls (anxiety:58.0% vs 9.4%, P<0.001; depression:43.0% vs 11.8%, P<0.001). Female, extraintestinal manifestations, and disease activity were associated with anxiety, while higher degree of education and disease activity were associated with depression. IBDQ and FACIT-F scores were significantly lower in patients with anxiety and depression (P<0.05). Conclusions The incidences of anxiety and depression in patients with CD are significantly higher than those in the general population. The risk of anxiety and depression is closely related to disease activity, and CD patients with anxiety and depression are more likely to have fatigue and lower health-related quality of life.