可降解聚对二氧环己酮材料的临床应用

背景：近年来诸多研究已经报道了聚对二氧环己酮的生物相容性、生物可吸收性和生物降解性；聚对二氧环己酮还在组织修复材料以及支架材料等医用领域有很好的应用。但聚对二氧环己酮的体内免疫反应评价及机制评价还有待于进一步研究，以更好地理解这些材料对免疫系统的作用。目的：总结和分析聚对二氧环己酮的降解特性及其在临床应用方面的研究进展。方法：应用计算机检索PubMed数据库(2000-01/2010-06)，以“polydioxanone,Absorbable”为检索词；应用计算机检索CNKI数据库(2000-01/2010-06)，以“聚对二氧环己酮”为检索词。共收集176篇关于聚对二氧环己酮临床应用的文献，中文39篇，英文137篇。排除发表时间较早，重复及类似研究，纳入25篇符合标准的文献。结果与结论：聚对二氧环己酮是一种具有良好生物相容性、生物可吸收性和生物降解性的脂肪族聚酯。其分子链中独特的醚键，使其还具有良好的柔韧性，是理想的手术缝合线材料，同时还可以用于制造骨板和组织修复材料以及电纺成心血管支架等，在医用领域具有广泛的应用前景。

Clinical application of biodegradable polydioxanone

BACKGROUND:Recent studies indicate that polydioxanone (PDO) has excellent biodegradability, bioabsorbability and biocompatibility, and it is widely used as tissue repair materials and scaffold materials in medical fields. However, the immunological reaction and mechanism evaluations in vivo need further investigation, so as to better understand the role of these materials in immune system.OBJECTIVE:To summarize and analyze the degradation characteristics of PDO and its clinical application progress.METHODS:A computer-based search of PubMed database and CNKI database (2000-01/2010-06) was performed using “polydioxanone, absorbable” in English and “polydioxanone” in Chinese as the key words. A total of 176 articles on the PDO clinical application were selected, including 39 Chinese and 137 English. The earlier published, repeated and similar studies were excluded, finally 25 articles were included in accordance with the criteria.RESULTS AND CONCLUSION:PDO, one kind of aliphatic polyesters, has excellent biodegradability, bioabsorbability and biocompatibility, and it also has good flexibility. So PDO is the ideal material for surgical suture. It is also used for laminates, tissue repair, electrospun cardiovascular graft and so on. PDO has a wide application prospect in clinical application.