低强度脉冲超声波对骨折愈合的影响

背景：随着人们寻求促进骨折愈合方法的同时,低强度脉冲超声波以其费用低廉、无创伤、无感染、治疗方便、无不良反应等优点逐步受到人们的关注与重视。目的：通过查阅大量相关资料并进行分析总结,从作用机制、动物实验和临床应用入手,对低强度脉冲超声波影响骨折愈合的研究现状进行综述,以期为促进骨折愈合提供新的思路和理论依据。方法：检索Pubmed数据库(http://www.ncbi.nlm.gov/Pubmed)(1989/2009)、维普数据库(www.cqvip.com) (1981/2009)和万方数据库(www.wanfangdata.com.cn) (1981/2009)的相关文章。英文检索词为“LIPUS,fracture”,中文检索词为“低强度脉冲超声波,骨折”。纳入与低强度脉冲超声波或超声波治疗骨折密切相关,同一领域选择近期发表或在权威杂志上发表的文章;排除重复性文献。文献类型包括综述、动物试验和临床试验等。计算机初检得到60篇文献,根据入选标准保留35篇文献做进一步分析。结果与结论：低强度脉冲超声波治疗骨折具有费用低廉、安全、环保、无创性、无感染、操作简便、适用范围广和并发症少等优点,动物实验和临床应用等证实低强度脉冲超声波是一种有效的促进骨折愈合的方法,目前公认的是要应用低频率、低强度。低强度脉冲超声波治疗骨折,不仅涉及物理学,而且涉及医学等多个学科,由于对超声波方面研究进展,以及机体的复杂性及伦理方面问题,其作用机制以及脉冲超声波参数值及各参数间该如何组合还有待进一步探索。

Effect of low-intensity pulsed ultrasound on bone fracture healing

BACKGROUND:Low-intensity pulsed ultrasound attracts much attention due to its low-cost, non-invasive, non-infection, convenient treatment, and no adverse reactions to promote bone fracture healing.OBJECTIVE:To review the effect of low-intensity pulsed ultrasound on bone fracture healing by mechanism, animal experiments, and clinical application so as to provide new ideas and theoretical evidences for promoting bone fracture healing.METHODS:The relevant articles in Pubmed database (http://www.ncbi.nlm.gov/Pubmed) (1989/2009), Vip database (www.cqvip.com) (1981/2009) and Wanfang database (www.wanfangdata.com.cn) (1981/2009) were retrieved. The index words were “LIPUS, fracture” in both English and Chinese. Inclusion criteria: articles which were closely related to the low-intensity pulsed ultrasound or ultrasound treatment of bone fracture healing and recently published or in authoritative magazines at the same field. The duplicated articles were excluded. The retrieval articles included reviews, animal experiments, and clinical experiments. Totally 60 literatures were primarily selected, 35 documents of which were involved for analysis according to inclusion criteria.  RESULTS AND CONCLUSION:Low-intensity pulsed ultrasound characterized by low cost, safety, environmental protection, non-invasive, non-infection, simple operation, wide application and less complications for treating bone fracture healing. Clinical experiments and clinical application have confirmed that low-intensity pulsed ultrasound was an effective method to promote bone fracture healing, characterizing by low frequency and low intensity. Bone fracture healing treated with low-intensity pulsed ultrasound involved in not only physics, but also medical and other disciplines. With the research progress of ultrasound, organic complexity, and ethics, the mechanism, parameters of low-intensity pulsed ultrasound and the combination of all parameters need to be further studied.