生物材料预防肌腱运动损伤后粘连及促愈合作用

背景：肌腱损伤后常见的并发症是肌腱粘连,其防治一直是医学界普遍关注的问题。目的：综述生物材料预防肌腱损运动伤后粘连及促愈合作用。方法：以“生物材料,肌腱损伤,预防粘连,修复”为中文关键词,“biologicalmaterial,tendon injury,prevent antistick,repair”为英文关键词,采用计算机检索1980-01/2010-12相关文章。纳入与生物材料与组织工程骨缺损修复相关的文章;排除重复研究或Meta分析类文章。结果与结论：肌腱损伤后的愈合包括内源性愈合、外源性愈合两种形式。防止肌腱粘连的理想途径,是通过改善肌腱的营养状况和周围环境,来促进内源性愈合,抑制或减轻外源性愈合。文章就目前常用的几种生物材料预防肌腱粘连的作用机制及特点进行了探讨,以便更好地发挥其预防肌腱粘连的作用。

Role of biological materials in preventing postsurgical adhesion and promoting tendon healing after sports injury

BACKGROUND:Tendon adhesion following sports injury is a big problem puzzling athletes for a long time, which affects training and sport technique. Its prevention has been a medical issue of common concern. OBJECTIVE:To review the effect of biological materials on preventing postsurgical adhesion and promoting tendon healing following sports injury.METHODS:Using “biological material, tendon injury, prevent antistickm repair” in Chinese and English as the key words, a computer search was performed for articles published between January 1980 and December 2010. Articles related to the biological materials and tissue engineering femoral defects were included; repeated study or Meta analysis articles were excluded. RESULTS AND CONCLUSION:Tendon healing following injury includes two forms, endogenous healing and exogenous healing. The ideal way to prevent tendon adhesion is to improve the nutritional state and the surrounding environment of the tendon so as to promote endogenous healing and restrain/ease exogenous healing. This paper explores the action mechanism and characteristics of several biomaterials in order to better play the role of biomaterials in prevention of tendon adhesion.