骨关节炎的转基因动物模型

背景：近年来随着转基因技术的发展,出现了骨关节炎的转基因动物模型,表明不同基因的缺失与突变都可能导致骨关节炎,这将为骨关节炎的药物筛选试验和治疗提供新方案。 目的：对骨关节炎的转基因动物模型的构建及其相关机制进行概述,为防治骨关节炎奠定理论基础。 方法：第一作者应用计算机检索1995/2010 PubMed数据库相关文章,检索词为“transgenic animal models,Osteoarthritis”,并限定文章语言种类为English。同时计算机检索2000/2010 中国知网数据库相关文章,检索词为“转基因动物模型,骨关节炎”并限定文章语言种类为中文。共检索到文章158 篇,最终纳入22篇。 结果与结论：骨关节炎转基因动物模型在研究骨关节炎起始机制、关节软骨生化改变和防治效果的比较等方面具有明显优势;排除了手术创伤及炎症对骨关节炎模型软骨、滑膜的生化代谢的影响;同时也减轻了模型动物的痛苦。为药物筛选试验和治疗提供新方案。

Transgenic animal models of osteoarthritis

BACKGROUND:In recent years, transgenic animal osteoarthritis models are presented with development of transgenic technology, which indicated that, different gene deletions and mutations may lead to osteoarthritis. This provides new plan of medicine screening and treats for osteoarthritis. OBJECTIVE:To summary the construction and relevant mechanisms with osteoarthritis of transgenic animal models, and to provide theoretical basis for prevention and treatment of osteoarthritis. METHODS:The first author retrieved PubMed database for English articles published from 1995 to 2010. The key words were “transgenic animal models, osteoarthritis”. Simultaneously, CNKI database was retrieved for relevant Chinese articles published from 2000 to 2010. A total of 158 articles were obtained, and finally 25 articles were included. RESULTS AND CONCLUSION:Osteoarthritis of transgenic animal models has obvious advantages in the study of the initial mechanism, biochemical changes in articular cartilage, prevention and treatment of osteoarthritis, which eliminate the influence by the surgical trauma and inflammation to the cartilage and the biochemical metabolism of synovial of osteoarthritis model, also relieve the pain of animals. This provides new plans for medicine screening and treats for osteoarthritis.