人工硬脑膜材料的生物相容性

背景：目前研究应用的硬脑膜修补材料主要有自体组织修补材料、同种异体材料、异种生物材料和人工合成材料。目的：评价修复硬脑膜缺损各种修补材料的性能和应用,寻找合理的硬脑膜修补材料。方法：以 “硬脑膜,材料”中文关键词,采用计算机检索中国期刊全文数据库2000-01/2010-12中相关硬脑膜缺损修补材料学研究及各种材料在硬脑膜缺损修补临床应用情况的文章。结果与结论：目前国内使用自体组织、同种异体材料、异种生物材料和人工合成材料等硬脑膜修补材料分别存在着来源困难、易粘连、不易保存、不易消毒或生物相容性差等缺点,自体组织修补材料在可利用的情况下仍为首选,其中异种生物材料因其良好的生物相容性及理化特性成为目前临床应用最广泛的硬脑膜修补材料。虽然异种生物材料是目前临床上大量使用的硬脑膜修补材料,但由于其存在各自不可避免的缺点,硬脑膜修复材料仍需进一步开发。

Biocompatibility of artificial dura materials

BACKGROUND:Dural repair materials in the application of present research are mainly including autologous tissue repair material, allograft material, heterogeneous biological materials and synthetic materials.OBJECTIVE:To evaluate the property and application of various repair materials in the repair of dural defects, and to find appropriate dural repair materials.METHODS:Taking “dural, material” in Chinese as search terms, the articles related to dural defect repair materials research and a variety of materials in the clinical application of dural defect repair from CNKI database (2000-01/2010-12) were retrieved.RESULTS AND CONCLUSION: At present autologous tissue, allograft materials, heterogeneous biological materials and synthetic materials and other dural repair materials respectively exist sources of difficulty, easy adhesion, difficult to preserve, not easily sterilized or poor biocompatibility disadvantages. Autologous tissue repair material was still the preferred material under usable circumstances, heterogeneous biological materials because of its good biocompatibility and physical and chemical properties become the most widely dural repair material in clinical application. Although heterogeneous biological materials is currently extensive use of dural repair material in clinic, because of respective inevitable shortcomings of them, dural repair material still needs further development.