组织工程人工骨材料修复长骨节段性缺损的现状与展望

背景：骨移植、人工替代物置换、骨延长等长骨节段性缺损修复方法虽已在临床上应用,但均有各自的局限性。 目的：就目前骨缺损的治疗加以回顾总结,并对长骨大段性缺损的修复方式作展望性分析。 方法：由第一作者检索PubMed数据库、中文生物医学文献期刊数据库2000-01/2010-12有关长骨大段性缺损修复的文章。英文关键词为“bone defect, bone tissue engineering,artificial bone,bone transplantation,therapy”,中文关键词为“骨缺损,骨组织工程,人工骨,骨移植,治疗”。排除标准陈旧性文章及重复性研究。 结果与结论：保留33篇文献进行文献证据提取。长骨节段性缺损的治疗包括自体骨移植、异体骨移植、骨延长、人工骨替代移植等,以组织工程人工骨的研究、利用为热点和主要发展方向,但以基础性研究和动物实验为多,少见于临床应用。组织工程人工骨在应用于临床长骨缺损治疗之前,尚存诸多问题急需解决,但仍为最有开发前景的骨缺损修复材料。

Tissue-engineered bone materials for repair of long bone segmental defects

BACKGROUND:Bone graft, artificial substitute replacement, bone lengthening and other repair methods for long bone segmental defects have been used in clinic, but they have their own limitations. OBJECTIVE:To review and summarize the current methods of bone defect treatment, and to analyze the developmental prospect of the treatment for the long bone defect. METHODS:The first author searched PubMed Database and Chinese Medical Current Contents to retrieve articles about long bone defect repair published 2000-01 to 2010-12. The keywords were “bone defect, bone tissue engineering, artificial bone, bone transplantation, therapy” in English and Chinese. Older articles and repetitive studies were excluded. RESULTS AND CONCLUSION:Thirty-three articles were included in final analysis. Repair methods for long bone segmental defects include autogenous bone graft, allograft, bone lengthening, bone substitute transplantation. Tissue engineered bone to repair bone defects has become the hot topic nowadays, but there are many urgent questions to be solved. The tissue engineered bone is a promising means of treating bone defects.