Prognostic value of red blood cell distribution width in predicting 3-month functional outcome of patients undergoing thrombolysis treatment for acute ischemic stroke |
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| Authors: | Dae Yong Kim Dae Young Hong Sin Young Kim Jeong Jin Park Jong Won Kim Sang O. Park Kyeong Ryong Lee Kwang Je Baek |
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| Affiliation: | aDepartment of Emergency Medicine, Konkuk University Medical Center, Seoul, Republic of Korea;bDepartment of Emergency Medicine, Konkuk University School of Medicine, Seoul, Republic of Korea;cDepartment of Neurology, Konkuk University School of Medicine, Seoul, Republic of Korea. |
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| Abstract: | This study was performed to determine whether red blood cell distribution width (RDW) is associated with 3-month poor functional outcome in patients undergoing thrombolytic therapy for acute ischemic stroke.RDW was measured in patients with thrombolytic therapy in emergency department. Functional outcome was assessed after 3 months and poor functional outcome was defined as modified Rankin scale 3 to 6.A total of 240 patients were enrolled, and 82 (34.2%) had a poor functional outcome. The median RDW was significantly elevated in patients with a poor functional outcome compare with those with a good outcome. RDW was independently associated with a 3-month poor functional outcome (odds ratio 3.369, 95% confidence interval 2.214–5.125). The optimal RDW cutoff for predicting 3-month poor functional outcome was 12.8%, and the area under the curve for RDW was 0.818 (95% confidence interval 0.761–0.876). The area under the curve for RDW was higher in male patients than in female patients. The RDW correlated positively with the modified Rankin scale score after 3 months and the initial National Institutes of Health Stroke Scale score.Initial higher RDW level is related to a 3-month poor functional outcome in patients undergoing thrombolytic therapy for acute ischemic stroke. |
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| Keywords: | cerebral infarction emergency department prognosis red cell distribution width stroke |
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