关节软骨修复与相关细胞因子的作用

背景：关节软骨损伤后几乎不能完全修复，在生理负荷下容易发生退行性改变，最终发展成骨性关节炎。利用细胞生长因子构建组织工程化软骨，修复重建受损关节软骨，为骨关节软骨疾病的治疗开辟了新的途径。目的：全面了解细胞因子特性与正常关节软骨相似的组织工程软骨的构建，明确目前细胞因子促进软骨分化修复的研究进展。方法：电子检索中国生物医学文献数据库和计算机Medline数据库1994/2009收录的关节软骨修复与相关细胞因子相关综述和论文报告，并分析其研究进展。结果与结论：共纳入软骨细胞因子相关文献29篇。关节软骨损伤后的修复非常有限，其对创伤、炎症的反应是由软骨细胞、滑膜组织分泌或关节液中含有的细胞因子所介导的。软骨细胞基质中的生长因子，通过不同的细胞信号通路使基因表达启动或关闭，在软骨生长和分化中发挥重要作用，同时软骨细胞周围环境因素也影响调控诱导分化的结果。

Repair of articular cartilages and relevant cytokines

BACKGROUND:Articular cartilages injuries are hard to repair completely, easily present with degenerative changes under physiological stress, and develop into osteoarthritis. It provides a new approach for the treatment of osteoarthritis using tissue-engineered cartilages to repair damaged articular cartilages.  OBJECTIVE:To overall understand the features of cytokines and construction of tissue-engineered cartilages similar to normal articular cartilage, and to identify the research process addressing promotive effect of cytokines on cartilage differentiation. METHODS:Chinese Biomedical Literature Database and Medline database were searched by computer for reviews and reports concerning repair of articular cartilages and cytokines, and the research process was analyzed. RESULTS AND CONCLUSION:Totally 29 documents were included. The repair of articular cartilage after damage is very limited, and its reaction to the wound and inflammation is mediated by cartilage cells and synovial tissues or cytokines in the joint fluids. Growth factors in chondrocyte matrix play an important role in cartilage growth and differentiation via regulating cell signal pathway; in addition, surrounding environment of chondrocyte also affects regulating cell differentiation.