脂肪干细胞在骨科基础研究中的新进展

背景：自脂肪来源干细胞被发现以来,培养传代及在支架材料上的生长能力就越来越受到骨科相关研究的关注。 目的：探讨脂肪来源干细胞的生物学特性及在骨科基础研究中的进展。 方法：由第一作者检索2001/2010 ISI Web of knowledge 数据库(网址http://www.isiknowledge.com)和PubMed 数据库(网址 http://www.ncbi.nlm.nih.gov/PubMed)有关脂肪来源干细胞培养特性和组织修复的相关文献并进行综合分析,检索词为“adipose derived stem cells,orthopaedic”。 结果与结论：脂肪来源干细胞具有与骨髓间充质干细胞相似的生物学特性及分化潜能,并且在骨骼、软骨、椎间盘、肌腱和韧带等组织的修复方面表现出良好的治疗效果。同时,脂肪来源干细胞在体内广泛分布,获取容易,为其在骨科相关疾病的修复治疗中奠定了良好的应用前景。

Progress of adipose-derived stem cells in orthopedics research

BACKGROUND:Adipose-derived stem cells (ADSCs) have become increasingly popular since it was discovered, which support a new way to treat orthopedic diseases. OBJECTIVE:To review the biological characterization and progress of ADSCs in orthopedic basic research, and provide powerful theoretical basis for further basic researches. METHODS:The first author retrieved ISI Web of knowledge database (http://www.isiknowledge.com) and PubMed database (http://www.ncbi.nlm.nih.gov/PubMed) for articles concerning the biological characterization of ADSCs and restoration of orthopedic diseases extensively published from 2001 to 2010. The key words were “adipose-derived stem cell,orthopaedic”. RESULTS AND CONCLUSIONS:ADSCs have similar characterization and multipotential differentiation as bone marrow-derived stem cells. Meanwhile, ADSCs reveal excellent results in defect repair of bone, cartilage, intervertebral disk, tendon and ligament. Furthermore, because of the abundance and ease of harvest, ADSCs can support adequate seed cells for cell engineering, tissue engineering and medicine researching. Therefore, ADSCs have manifested broad prospects in therapy of orthopedic diseases, which deserve a further investigation.