血管内皮生长因子复合人工骨材料修复骨缺损

背景：由创伤、感染、肿瘤切除以及某些先天性疾病等所导致的四肢骨缺损的治疗仍是骨科临床最常见、最棘手的一大难题。目的：文章综述了血管内皮生长因子的生物学特性、及其复合人工骨的作用机制、局部基因治疗在治疗骨缺损中的应用。方法：应用计算机检索CNKI和PubMed数据库中1999-01/2009-12关于血管内皮生长因子和骨缺损修复相关的内容的文章,在标题和摘要中以“血管内皮生长因子,骨缺损,人工骨,基因治疗”或“VEGF,Bone defect,Bone substitute,Gene therapy”为检索词进行检索。选择文章内容与血管内皮生长因子和骨缺损修复相关,同一领域文献则选择近期发表或发表在权威杂志文章。结果与结论：初检得到285篇文献,根据纳入标准选择45篇文章进行综述。血管内皮生长因子是增加血管渗透性和血管发生的特殊生长因子,在骨的生长、发育和重建中密切协调血管发生和骨发生的关系,而目前的人工骨材料只具有传导成骨的特性,所以改善人工骨材料中的血管生成可促进血运丰富骨组织的形成。

Reparation of segmental defects by vascular endothelial growth factor combined with bone substitutes

BACKGROUND:The therapy for limb defects caused by injury, infection, tumor excision and congenital diseases is one of the commonest and most thorny problems in orthopedic clinics. OBJECTIVE:To summarize the biological characteristics of vascular endothelial growth factor (VEGF), the mechanism of composite artificial bone and the application of regional gene therapy in bone defects.METHODS:A computer-based online search of CNKI database and Pubmed database from January 1999 to December 2009 was performed for relative articles about VEGF and bone defect repair, with key words of “VEGF, Bone defect, Bone substitute, Gene therapy” in English and in Chinese by screening titles and abstracts. The documents that associated with VEGF and bone defect repair were selected, and those published recently or in authoritative journals were preferred in the same field.RESULTS AND CONCLUSION:Totally 285 articles were obtained in initial retrieval, 45 articles of them were chosen to summarize based on inclusion criteria. VEGF is a special growth factor promoting vascular permeability and angiogenesis, and it plays close coordination role between angiogenesis and osteogenesis in the growth, development and reconstruction of bone. Present artificial bone materials only have characteristics of conducting osteogenesis. Thus improving the angiogenesis of artificial bone materials can promote the formation of bone tissue with abundant blood supply.