几丁糖防治运动损伤后的肌腱粘连

背景：肌腱损伤是运动训练中的常见损伤,在肌腱损伤修复过程中易形成粘连,从而使肌腱原有的功能下降或丧失。目前受到国内外学者瞩目的防治肌腱粘连的方法是防粘连材料的应用,在众多材料中,几丁糖备受关注。 目的：综述了几丁糖防治运动损伤后的肌腱粘连。 方法：应用计算机检索CNKI和PubMed数据库中1990-01/2010-12关于几丁糖防治运动损伤后肌腱粘连的文章,在标题和摘要中以“几丁糖,肌腱,粘连,运动损伤”或“chitosan,tendon,adhesion,sports injury”为检索词进行检索。选择文章内容与几丁糖防治运动损伤肌腱粘连相关,同一领域文献则选择近期发表或发表在权威杂志文章。根据纳入标准选择29篇文章进行综述。 结果与结论：肌腱主要由胶原纤维组成,其生物力学特性与胶原纤维密切相关。肌腱损伤后的愈合过程通过外源性愈合和内源性愈合两条途径完成,外源性愈合是产生粘连的主要原因。动物实验及临床实验均表明几丁糖具有良好的预防肌腱粘连的效果,其作用机制主要有降低胶原纤维的产生、屏障隔离、加速止血、抗菌消炎等。因此几丁糖是一种较为理想的预防肌腱粘连的物质,但应用中仍发现一些问题有待解决。

Chitosan prevents tendon adhesion after sports injury

BACKGROUND:Tendon injury is common seen in sports exercise, and tendon adhesion often occurs during the repair of tendon injury. Tendon adhesion can damage tendon function. At present, chitosan is a hotspot for prevention of tendon adhesion. OBJECTIVE: Toreview the effect of chitosan on post-sports tendon adhesion. METHODS: A computer-based search of CNKI and PubMed from January 1990 to Decembe 2010 was performed with keywords of “chitosan, tendon, adhesion, sports injury” in Chinese and English to retrieve the articles about chitosan for prevention of tendon adhesion after sports injury. Related articles published recently or in authoritative journals were selected. According to the inclusion criteria, 29 papers were selected. RESULTS AND CONCLUSION:The tendon is mainly composed of collagen fibers, and its biomechanical properties are closely related to collagen fibers. The healing process of tendon injury consists of two ways: exogenous and endogenous healing. Tendon adhesion often occur in exogenous healing. Previous animal experiments and clinical studies have demonstrated that chitosan has a good preventive effect on tendon adhesion, which mechanisms include reducing the production of collagen fibers, barrier isolation, hemostasis acceleration, and antisepsis and anti-inflammation. Therefore, chitosan is an ideal material to prevent tendon adhesion, but there are still some problems in clinical application to be resolved.