医用生物材料在肌腱损伤后粘连修复中的应用

背景：选用何种生物材料预防肌腱粘连，是目前医学界研究的热点。目的：总结近年生物材料在肌腱损伤术后粘连修复中的应用现状。方法：由作者应用计算机检索1999-01/2009-10维普数据库，选择生物材料修复肌腱损伤术后粘连的有关文章，共入选相关文献30篇。结果与结论：几丁糖具有良好的生物学特性，是一种无毒、无刺激性、无抗原性、组织相容性良好、在体内可降解吸收的新型医用生物材料，具有显著预防肌腱粘连作用。医用生物蛋白胶具有优良的止血与封闭作用、良好的生物相容性、生物降解功能，一定的杀菌作用，可减少和控制创伤炎症反应。大量临床研究及动物实验研究显示医用透明质酸钠、明胶海绵、糜蛋白酶等均具有防止术后组织粘连的作用。

Biomedical materials for adhesion repair after tendon injury

BACKGROUND:Selection of biomaterials against tendon adhesion is a hotspot in the medical field. OBJECTIVE:To summarize the clinical application of biomaterials in adhesion repair following tendon injury.METHODS:A computer-based search of VIP database (1999-01/2009-10) was performed for articles about biomaterials for postoperative adhesions after tendon injury. Totally 30 articles were included.RESULTS AND CONCLUSION:Chitosan has good biological properties, which is a non-toxic, non-irritating, non-antigenic, and biodegradable biomaterial with good tissue compatibility, and it has a significant role in the prevention of tendon adhesion. Biomedical fibrin glue has a fine hematischesis and sealing function, good biocompatibility, favorable biodegradation function and a certain sterilization, which can reduce and control traumatic inflammation reactions. Numerous clinical studies and animal studies have shown that medical sodium hyaluronate, gelatin sponge, and chymotrypsin have a preventive role in postoperative tissue adhesion.