骨填充材料在骨肿瘤中的应用

背景：由于肿瘤造成的骨组织缺损是临床面临的难题之一，而如何修复骨缺损是骨科领域的热点问题。 目的：介绍各种骨填充材料在骨肿瘤中的应用，并观察硫酸钙人工骨复合自体骨修复骨肿瘤骨缺损的临床疗效。 方法：以“骨填充材料，骨肿瘤，骨缺损”为中文关键词；以“bone filled materials，bone tumor，bone defect”为英文关键词，采用计算机检索2001-01/2011-01 PubMed及CNKI数据库相关文章。共检索到文献40篇，最终纳入符合标注的文献24篇。 结果与结论：用于骨肿瘤骨缺损的骨填充材料众多，主要分为自体骨、同种异体骨、人工合成材料。有学者应用复合材料取得了较好的疗效。每种材料在修复骨肿瘤骨缺损中都有各自的优缺点。到目前为止，还没有发现一种理想的骨肿瘤骨缺损填充材料。通过骨组织工程技术获得所需的骨填充材料，可能是今后的发展方向之一。

Bone filling materials in bone tumors

BACKGROUND:Bone tissue defects due to bone tumor are a difficult problem in clinic, and how to repair bone defects is a hotspot in the orthopedics. OBJECTIVE:To introduce the application of different bone filling materials in bone tumors, and to observe the clinical effects of calcium sulfate bone graft combined with autologous bone to repair bone defects induced by bone tumors. METHODS:A computer-based search of PubMed and CNKI was performed to retrieve relavent articles published 2001-01/2011-01 using the keywords of “bone filled materials, bone tumor, bone defect” in English and Chinese, respectively. Totally 40 articles were retrieved, and finally 24 met the requirment. RESULTS AND CONCLUSION:Bone filling materials for bone tumor-induced bone defects are mainly divided into autologous bone, allograft bone, artifical materials. Some scholars have achieved good results by using composite materials. Each kind of materials has its own advantages and disadvantages in the repair of bone defects. Up to now, there is not an ideal filling material for bone defects. The bone filling materials produced by using bone tissue engineering technology may be one of the future developmental direction.