内皮祖细胞与雌激素

背景：研究发现雌激素对血管内皮具有明显的保护作用,而内皮祖细胞作为内皮细胞的前体细胞参与内皮的修复。 目的：总结内皮祖细胞生物特点及雌激素对内皮祖细胞作用的研究进展。 方法：应用计算机检索PubMed数据库及CNKI数据库,在标题和摘要中以“内皮祖细胞,雌激素”或“Endothelial progenitor cells,estrogen”为检索词进行检索。选择与内皮祖细胞生物学特点及雌激素对其作用研究相关的文献。 结果与结论：内皮祖细胞存在于骨髓和外周血中,是具有增殖、迁移、黏附能力并分化为血管内皮细胞潜能的原始细胞,可作为未来治疗心血管疾病的重要的靶点。雌激素对内皮祖细胞有保护效应,能增强内皮祖细胞增殖、迁移、黏附等生物活性,同时还能延迟内皮祖细胞衰老、拮抗其凋亡。但雌激素影响内皮祖细胞生物活性的具体靶点及机制尚有待进一步研究。

Endothelial progenitor cells and estrogen

BACKGROUND: Estrogen has obviously protective effect on vascular endothelium. Endothelial progenitor cells (EPCs), as precursors of endothelial cells, take an important role in endothelial recovery. OBJECTIVE:To summarize the characteristics of EPCs as well as the effect of estrogen on EPCs. METHODS:A computer search of PubMed database and CNKI database was performed using the keywords of “endothelial progenitor cells, estrogen” in English and Chinese, respectively, in the titles and abstracts. All articles related to the characteristics of endothelial progenitor cells and studies about the effect of estrogen on EPCs were selected. RESULTS AND CONCLUSION:EPCs are the precursors of endothelial cells which have the capacity of proliferation, migration, adhesion and differentiation into vascular endothelial cells. EPCs are existing in both bone marrow and peripheral blood, which has become a new therapy target of cardiovascular diseases. Studies have shown that estrogen has protective effect on EPCs: estrogen can improve the proliferation, migration, adhesion and other bioactivities of EPCs, and EPCs senescence are delayed and apoptosis of EPCs are reduced by estrogen treatment. Further research is needed to clarify the specific targets and mechanisms involved in the effect of estrogen on EPCs.