富血小板血浆在骨愈合治疗中的作用

背景：富血小板血浆可明显促进各种组织的修复和愈合。临床上运用其治疗骨软骨以及软组织缺损等骨科疾病方面已取得了很多成果。 目的：简要综述近年来富血小板血浆相关研究，总结其在骨科基础研究与临床应用中的进展。 方法：以“platelet-rich plasma, bone formation, tissue engineering”为检索词，检索Pubmed数据库(1999-01/2011-01)，以“富血小板血浆，骨缺损，组织工程”为检索词，检索中国期刊全文数据库(1999-01/2011-01)。纳入与干细胞以及干细胞在骨科应用方面的基础和临床研究，排除不相关及重复研究。计算机初检得到301篇文献，根据纳入排除标准，最终纳入62篇。 结果与结论：尽管目前还存在争论，但富血小板血浆仍是一种非常有潜力的技术，尤其是作为细胞支架在组织工程中的应用如能被进一步研究证实有效，将对骨组织工程乃至其他各种组织工程研究产生重大的影响。因此除了规范研究在循证医学方面的要求之外，这应该是富血小板血浆今后研究的有一个重要方向。

Application of platelet-rich plasma in treatment of bone repair

BACKGROUND:Platelet-rich plasma (PRP) is capable to enhance the repair of many kinds of tissue. It is now more and more used to treat the bone or soft tissue deficiency in orthopedic clinics. OBJECTIVE:To summarize the new progress of PRP and its applications in orthopedics in recent years. METHODS:A compute-based online search of Pubmed database from January 1999 to January 2011 and China National Knowledge Infrastructure from January 1999 to January 2011 was performed using the key words of “platelet-rich plasma, bone formation, tissue engineering”. The experimental studies about PRP and clinical applications in orthopedics were included. Repeated or out-of-date studies were excluded. Totally, 301 articles were collected and finally 48 were included according to inclusion and exclusion criteria. RESULTS AND CONCLUSION:Although with controversy, PRP is a promising technique, especially as scaffold of tissue engineering. It would be very helpful in development of bone tissue engineering. Besides standardized the research protocol by evidence-based medicine, it should be a very important research direction.