神经干细胞与帕金森病

背景：帕金森病已经成为中老年人常见的运动障碍性疾病之一,目前对其治疗的主要方式仍然是在药物和手术等领域,而神经干细胞作用于帕金森病的功能康复已经受到国内外学者的广泛关注。 目的：在分析神经干细胞的生物特性及其帕金森病的病理特征的基础上,探讨了神经干细胞对帕金森病的作用,旨在为神经干细胞移植促进帕金森病康复的应用提供科学依据。 方法：应用计算机检索Medline数据库、CNKI数据库和维普数据库(1994-01/2010-08)以“Parkinson disease,Neural Stem Cell,Rehabilitation”为英文检索词,以“帕金森病;神经干细胞;康复”为中文检索词,通过对与帕金森病、神经干细胞等的相关文献,以权威期刊、近年来发表的文献作为纳入标准,以重复性研究、陈旧性研究为排除标准等,对所得文献进性整理分析。 结果与结论：神经干细胞作用于帕金森病患者的康复具有取材方便、低免疫原性、多向分化潜能、可定向诱导分化等优势,被作为治疗包括帕金森病在内的神经损伤类疾病的新的手段,但如果要将神经干细胞真正应用于临床治疗仍需要不断的开展研究,主要体现在对于神经干细胞得分化和功能修复机制还不清楚,移植后的细胞能否与体内损伤细胞相整合,建立起正常得神经系统突触联系还需要进一步研究。

Neural stem cells and Parkinson disease

BACKGROUND:Parkinson disease in the elderly has become a common movement disorders, currently its main form of treatment is still in the fields of medicine and surgery, and the role of neural stem cells in functional recovery in Parkinson's disease has been domestic and foreign scholars’ attention. OBJECTIVE:To explore the effect of neural stem cells on Parkinson disease based on the analysis of biological characteristics of neural stem cells and pathological features of Parkinson disease, in order to provide a scientific basis for rehabilitation of Parkinson disease promoted by neural stem cells transplantation. METHODS: Acomputer based online search of Medline database, CNKI database and VIP database (1994-01/2010-08) was performed with the key words of "Parkinson disease, neural stem cell, rehabilitation" in English and Chinese, respectively. According to the relevant literature of Parkinson disease and neural stem cells, articles published in recent years or in authorized journals were included. Duplicated and outdated articles were excluded. The standard literatures were involved for analysis. RESULTS AND CONCLUSION: Through research we found that neural stem cells in the rehabilitation of patients with Parkinson disease have many advantages, such as their materials can be easily obtained, low immunogenicity and orientable differentiation. Neural stem cells transplantation has been served as a treatment for nerve damage, including Parkinson disease. But if neural stem cells are applied to clinical treatment, it is still need to be constantly researched. The differentiation and mechanisms of functional repair in neural stem cells are unclear. Whether cells can be integrated with injury in vivo after transplantation to establish normal synaptic connections also need to be further studied.