激素性股骨头坏死与他汀类药物的修复治疗作用

背景：近年来随着器官移植技术在临床上的广泛开展,糖皮质激素引起股骨头缺血性坏死占到首位,且并有逐年增高的趋势。 目的：主要对他汀类药物治疗股骨头坏死的机制进展进行综述分析,为进一步的实验研究及临床应用奠定基础。 方法：第一作者应用计算机检索CNKI、PubMed、万方和维普数据库中1980-01/2010-12关于他汀类药物在治疗股骨头坏死机制的文章,在标题和摘要中以“股骨头坏死;他汀类药物;糖皮质激素;成骨细胞”或“ONFH;Corticosteroids;  statins;  Osteoblasts”为检索词进行检索。选择文章内容与激素性股骨头坏死与他汀类药物修复治疗相关,同一领域文献则选择近期发表或发表在权威杂志文章。排除陈旧及重复实验文章,初检得到169篇文献,根据纳入标准选择34篇文章进行综述。 结果与结论：股骨头缺血性坏死是骨科常见,多发性的疾病,其治疗是世界性的难题。他汀类药物能有效纠正激素所导致机体内脂质代谢紊乱的状态,减轻股骨头内的骨细胞损害,可以延缓或阻止股骨头缺血坏死、塌陷、变形的病理过程。

Repair of osteonecrosis of the femoral head with statins

BACKGROUND:In recent years, with the development of organ transplant technology in clini, osteonecrosis of the femoral head caused by corticosteroids accounts for the first place that has an increased trend year after year. OBJECTIVE:To review the mechanism of statins drugs in the treatment of osteonecrosis of the femoral head providing the foundation for further experimental research and clinical application. METHODS:The first author searched CNKI, PubMed, Wanfang and VIP databases in 1980-01/2010-12 to retrieve articles about the mechanism of statins used in the treatment of avascular necrosis of the femoral head. The keywords were “avascular necrosis of the femoral head; statins; glucocorticoids; osteoblast” or “ONFH; corticosteroids; statins; osteoblasts” in Chinese and English, respectively. Articles published recently or in authorized journals were preferred. Old and repetitive experimental articles were eliminated, 169 articles were checked; and according to inclusion criteria, 34 articles were reviewed. RESULTS AND CONCLUSION:Osteonecrosis of the femoral head is a common and multiple diseases in the field of orthopedics, and its treatment is a difficult task facing the world. Research shows that statins can effectively correct lipid metabolism disorders, reduce bone cell damage in the femoral head, and slow or stop the pathological process of osteonecrosis, deformation and collapse.