电针抑制骨性关节炎的炎症反应及延缓关节软骨退变

背景：研究表明基质金属蛋白酶3在关节软骨退变和破坏中有重要意义。目的：观察长针透刺与透明质酸钠治疗大鼠膝骨关节炎后，大鼠化膜组织中基质金属蛋白酶3含量变化。方法：SD大鼠通过膝关节腔内注射1.6%木瓜蛋白酶溶液并驱赶大鼠活动建立膝骨关节炎模型。造模2周后随机分为3组，长针透刺组用直径0.30 mm、长125 mm规格的毫针透刺大鼠犊鼻穴和膝眼穴；药物治疗组关节腔内注射透明质酸钠；模型组不干预。并设立不造模的正常组。结果与结论：治疗4周后，模型组大鼠滑膜组织基质金属蛋白酶3含量较正常组显著升高(P < 0.05)，长针透刺组、药物治疗组基质金属蛋白酶3含量较模型组显著降低(P < 0.05)，长针透刺组与药物组相近(P > 0.05)。证实长针透刺疗法能有效纠正膝骨关节炎模型大鼠化膜组织中基质金属蛋白酶3的异常表达，这也可能是长针透刺治疗膝骨关节炎的作用原理之一。

Electro-acupuncture treatment inhibits inflammatory reaction and postpones articular cartilage degeneration in osteoarthritis

BACKGROUND:Several studies have shown that electro-acupuncture (EA) can effectively alleviate the clinical symptoms of osteoarthritis.OBJECTIVE: Toinvestigate the mechanism by which EA treatment inhibits osteoarthritis inflammation and protects the function of articular cartilage. METHODS:SD rat models of osteoarthritis were established by double knee joint cavity injection of papain. Osteoarthritis rat models were treated with EA at EX-LE4 and EX-LE5 for 5, 15 and 30 minutes per day. RESULTS AND CONCLUSION:Compared with the model group, substance P in blood and interleukin 1, interleukin 6, tumor necrosis factor α, matrix metalloproteinase 3 concentrations in synovial fluid were significantly reduced, leptin in blood and matrix metalloproteinase 1 in synovial fluid were significantly increased (P < 0.05), and the degree of cartilage degeneration was significantly alleviated (P < 0.05, P < 0.01) in osteoarthritis rat models after treatment with EA for 15 and 30 minutes per day  (P < 0.05). These results showed that EA can effectively alleviate the inflammatory reaction and postpone articular cartilage degeneration in osteoarthritis.