新型羟基磷灰石多孔支架的制备与性状

背景：目前几种钙羟磷灰石作为骨的替代品已经在临床上使用，但是由于缺少内部交互的连通孔，使得骨形成过程中经常发生病理性的骨折。 目的：采用改良的技术制备互联多孔羟磷灰石陶瓷支架材料，并对其物理化学特征进行检测。 方法：将羟基磷灰石(质量分数60%)与聚乙烯亚胺质量分数40%混合，采用改良的泡沫凝胶技术技术(聚氧乙烯十二烷基醚质量分数1%)制备多孔羟磷灰石陶瓷。扫面电镜检测材料内部结构，将制备的材料移植动物体骨缺损区观察成骨情况。 结果与结论：多孔羟磷灰石陶瓷具有三维结构，内部充满大小较均一的球形孔隙，直径平均为150 μm，孔隙率75%，孔隙上充满窗孔样相互交通的小洞，平均40 μm, 具有足够的抗压度(10~12 MPa)。动物实验表明，多孔羟磷灰石陶瓷表现出较好的成骨诱导性，可见孔隙里形成了新生骨。结果提示改良的羟基磷灰石支架能够在骨组织工程上应用，有望成为新型的改良品。

Preparation an proterties of interconnected porous hydroxyapatite scaffold

BACKGROUND:Several kinds of hydroxyapatite has been applied in clinics as bone substitute, pathologic fracture often occurs in bone formation process for lack of interconnection hole. OBJECTIVE:To prepare the porous interconnected hydroxyapatite ceramic scaffold materials by modified technique, and to determine the physical-chemical characteristics of the materials. METHODS:Interconnected porous hydroxyapatite ceramics were prepared by mixing hydroxyapatite (60% volume fraction) and polymine (40% volume fraction) using modified foam-gel technic (polyoxyethylene lauryl ether 1% volume fraction). The inner structural characteristic of the material were detected by scanning electron microscopy. The prepared material was transplanted into the bone defect zone, and the new bone formation was observed. RESULTS AND CONCLUSION:The interconnected porous hydroxyapatite ceramics have three-dimensional structure, it is full of uniform pores (150 μm in diameter, 75% porosity). It is also filled with interconnective holes (40 μm in diameter) at the wall of pores and has enough compressive strength (10-12 MPa). Animal experiment showed Interconnected porous hydroxyapatite ceramics have excellent bone inductivity, new forming bone forms in the pores. Improved hydroxyapatite ceramics may be applied in the bone tissue engineering and may become new substitute.