他汀类药物对内皮祖细胞的相关作用

背景：他汀类药物作为临床上广泛应用的降脂类药物，其不同剂量与疗程对于内皮祖细胞有着不同的近期及远期作用。 目的：综述国内外他汀类药物对内皮祖细胞作用的现状和进展。 方法：应用计算机检索CNKI和Pubmed数据库中1995-01/2009-11关于内皮祖细胞和他汀类药物的文章，在标题中以“内皮祖细胞，他汀类药物”或“endothelial progenitor cells，statins”为检索词进行检索。选择文章内容与内皮祖细胞及他汀类药物有关者，同一领域文献则选择近期发表或发表在权威杂志文章。初检得到843篇文献，根据纳入标准选择关于内皮祖细胞及他汀类药物的19篇文献进行综述。 结果与结论：他汀类药物对于内皮祖细胞有多重的作用。在短期治疗和低剂量的情况下，对心血管疾病有保护作用，增强内皮祖细胞各方面功能；在长期、大剂量应用他汀类药物后，造成其数量减少，抑制了血管生成，这对于抑制肿瘤血管发生有一定的研究价值。

Statins effects on endothelial progenitor cells

BACKGROUND:As the statins are widely used as clinical lipid-lowering drugs, and their different dosages and treatment periods may have short and long-term effects on endothelial progenitor cells (EPCs). OBJECTIVE:To summarize the investigative situation and progression about the effects of statins on EPCs. METHODS: We used the databases of China National Knowledge Infrastructure and Pubmed (1995-01/2009-11) to search relevant articles about EPCs and statins. “Endothelial progenitor cells”, “statins” were taken as key words and then selected some relevant articles. Articles in the same field published recently or in authoritative journals were included. There were 843 articles after the initial survey. Then 19 articles involving statins and EPCs were selected according to inclusion criteria. RESULTS AND CONCLUSION:Statins have multiple effects on EPCs. In the short-term treatment with the low dosage of statins, statins show the protective effects on EPCs against cardiovascular disease, enhancing the function of all aspects of EPCs. The result of the long-term treatment with high-dosage of statins decreases the number of EPCs and inhibites angiogenesis, which reveals the research value for inhibiting tumor angiogenesis.