内皮祖细胞生物学特征及其临床应用

背景：内皮祖细胞已经广泛用于研究缺血性疾病,能促进内皮再生、血管修复及组织中新生血管形成。 目的：综述内皮祖细胞生物学特征及其临床应用的研究进展。 方法：应用计算机检索1997-01/2010-12 PubMed数据库相关文章,检索词为“endothelial progenitor cells,ischemic cerebrovascular disease,early endothelial progenitor cells,late endothelial progenitor cells”,共检索到文献219篇,最终纳入符合标准的文献28篇。 结果与结论：内皮祖细胞定居于成体骨髓,现已证实胎肝、人脐血、成人外周血及骨髓中均存在,且人脐血、外周血中的内皮祖细胞均来源于骨髓。此外在心脏、血管、脂肪组织和骨骼肌等外周组织中也发现内皮祖细胞的存在。内皮祖细胞具有促进内皮再生及血管修复的功能,能促进组织中新生血管形成,在防治血管成形术后再狭窄等血管性疾病中发挥重要作用,其中晚期内皮祖细胞比早期内皮祖细胞更易形成毛细血管,在干细胞移植临床应用于缺血性脑卒中具有广泛的前景。

Biological characteristics and clinical application of endothelial progenitor cells

BACKGROUND:Endothelial progenitor cells have been widely used in the research of ischemic diseases, and they can promote endothelial regeneration, repair vessels and promote new vessels formation in tissue. OBJECTIVE:To review research progress in biological characteristics and clinical application of endothelial progenitor cells. METHODS:We retrieved PubMed database with the key words of “endothelial progenitor cells, ischemic cerebrovascular disease, early endothelial progenitor cells, late endothelial progenitor cells” for relevant articles published from January 1997 to December 2010. Totally 219 literatures were screened out by computer, and finally 28 papers were involved in the analysis. RESULTS AND CONCLUSION: Endothelial progenitor cells are found in fetal liver, human umbilical cord blood, adult peripheral blood and bone marrow. Endothelial progenitor cells from human umbilical cord blood and peripheral blood are derived from bone marrow. In addition, in the heart, blood vessels, adipose tissue and skeletal muscle tissues, there is also presence of endothelial progenitor cells. Endothelial progenitor cells can promote endothelial regeneration, repair vessels and promote new vessels formation in tissue. They play an important role in fighting against stent restenosis. Compared to early endothelial progenitor cells, late endothelial progenitor cells are more likely to form capillaries, and have a wide range of application prospects for stem cell transplantation in the treatment of cerebral ischemic stroke.