高龄亲属活体供肾移植7例中长期效果：同一机构2年资料回顾分析

背景：随着肾移植中肾供体的短缺,“边缘”供肾提供了一条缓解途径。目的：观察高龄亲属活体供肾移植的安全性和中长期临床效果。 方法：回顾性分析随访36~64个月的7例≥65岁亲属活体供肾移植的供者和受者的临床资料。结果与结论：供、受者移植后均恢复顺利,无严重并发症。受者1周内移植肾功能正常、供者肾功能较术前略有增高、但均在正常范围内。无排斥反应发生。5例人/肾正常存活36~64个月;2例移植后≥1年死亡。供者均正常存活,无蛋白尿、高血压,肾功能正常。提示≥65岁高龄亲属活体供肾应经过严格筛选,部分可为临床扩大供肾来源。

Living-related donor kidney transplantation in elderly donors: A retrospective case analysis from one institute during 2 years

BACKGROUND: The donors from “marginal” kidneys have been accepted to partly solve the problem between limited supply and increasing demand.OBJECTIVE:To investigate the safety of living-related donor kidney transplantation from donors above 65 years old and the middle- and long-term clinical efficacy. METHODS:The clinical data of seven pairs of donors and recipients who underwent living-related donor kidney transplantation from donors ≥ 65 years old and were followed up for 36-64 months.  RESULTS AND CONCLUSION: The donors and recipients recovered smoothly post-surgery with no severe complications. The function of kidney grafts recovered to normal within 1 week after surgery, the kidney function of donors was improved compared with prior to surgery, but it was within normal range. No acute rejection was found. Five recipients survived with normal kidney graft for 36-64 months, and two cases died one year after surgery. All donors survived with no proteinuria or hypertension, but with normal kidney transplantation. These findings suggest that kidney grafts from donors ≥65 years old may be allowed for living-related donor kidney transplantation after strict screening, which can expand the donor pool in the clinic.