老年与青年尿毒症患者群体反应性抗体产生频率的比较

背景：目前众多研究证实,肾移植前患者体内群体反应性抗体的存在与否及该抗体的致敏程度对于是否发生排斥反应及移植物存活率的高低、移植后器官功能的实现都有着重要意义。目的：对比分析老年和青年尿毒症患者移植前产生群体反应性抗体的频率。方法：选择402例待做肾移植的尿毒症患者,其中青年组尿毒症患者226例,男179例,女47例;高龄组尿毒症患者176例,男88例,女88例。凡是年龄小于35岁以下和大于50岁以上的尿毒症患者均在统计之内。通过酶联免疫吸附实验筛查受者移植前血清中HLA-IgG抗体。结果与结论：青年组尿毒症患者群体反应性抗体阳性14例;老年组尿毒症患者群体反应性抗体阳性32例,两组间比较差异有显著性意义(P < 0.005)。青年组中男性群体反应性抗体阳性10例,女性群体反应性抗体阳性4例,男女间群体反应性抗体阳性率比较差异无显著性意义(P < 0.05);老年组中男性群体反应性抗体阳性10例,女性群体反应性抗体阳性22例,男女间比较差异有显著性意义(P< 0.05)。说明老年尿毒症患者群体反应性抗体产生的频率高于青年尿毒症患者,并且老年女性患者群体反应性抗体产生的频率高于老年男性患者。

Comparison of panel reactive antibody incidence between old and youth uraemic patients

BACKGROUND:In recent year, many research show the presence of panel reactive antibody and its sensitization degree have great significance with rejection reaction, graft survival and graft function realization. OBJECTIVE:To investigate the difference of human leucocyte antigen (HLA) antibody incidence between old and youth uraemic patients. METHODS:A total of 402 uraemic patients waiting for renal transplantation were selected, including 226 youth patients, 179 males and 47 females; and 176 old patients, 88 males and 88 females. All uraemic patients aged smaller than 35 or greater than 50 years old were analyzed. The serum HLA-IgG antibody in recipients was detected using ELISA.  RESULTS AND CONCLUSION:Totally 14 patients showed PRA positive in the youth group, which was 32 in the old group, there was obviously difference (P < 0.005). In the youth group, 10 males and 4 females showed PRA positive, and there was no significant difference in PRA positive incidence between male and female patients (P < 0.05); in the old group, 10 males and 22 females showed PRA positive, with significant difference (P < 0.05). There is significant difference in PRA positive between old and youth group. The findings demonstrated that incidence of PRA in the old uraemic patients is greater than youth uraemic patients, and it shows great difference between males and females in old group.