急性冠脉综合征患者血清高敏C反应蛋白和组织蛋白酶S水平变化与临床意义

目的：探讨血清高敏C反应蛋白（hs—CRP）、组织蛋白酶S（CatS）与急性冠脉综合征的相关关系。方法：选择53例急性冠脉综合征患者（ACS组），对照组36例，检测两组血清CatS、hs—CRP水平并进行比较。同时检测ACS组治疗后血清hs—CRP、Cats水平的变化。结果：ACS组在性别、年龄、吸烟、糖尿病、脑梗死、高血压患病率方面与对照组相比，差异无统计学意义（P〉0．05）；ACS组治疗前血清CatS水平为（0．51±0．03）nmol／L，hs—CRP为（10．21±5．03）mg／L，分别高于对照组的（0．43±0．04）nmol／L和（3．64±1．87）mg／L，差异具有统计学意义（P〈0．05）；ACS组治疗后血清CatS、hs—CRP水平分别为（0．45±0．06）nmol／L和（6．05±3．25）mg／L，较治疗前的（0．51--4-0．03）nmol／L和（10．21±5．03）mg／L明显降低，差异有统计学意义（P〈0．05）。结论：ACS患者血清CatS及hs—CRP的水平的变化提示CatS及hs—CRP可能在ACS发生发展过程中具有重要作用，推测CatS可能作为ACS的一种新的生物标志物。

Changes of hs-CRP, CatS level in acute coronary syndrome patients serum and clinical significance

AIM： To investigate the serum high sensitive creactive protein （hs-CRP）, ca-thepsin S （CatS） level changes and clinical sig- nificance in acute coronary syndrome patients.METHODS： All patients were divided into acute coronary syndrome （ACS group, n= 53） and control group（n= 36）. The levels of serum hs- CRP and CatS in two groups were detected and compared before and after treatment. RESULTS： There were no significant difference of two groups in gender, age, smoking, diabetes, cere- bral infarction, hypertension prevalence rate. The levels of serum CatS and hs-CRP in ACS group before treatment and control group were （0.51±0.03） nmol/L, （10.21±5.03） mg/L and （0.43 ± 0.04） nmol/L, （3.64 ± 1.87） rag/L, respectively there were statistically sig- nificant differences （P〈 0.05 ）. After treatment, the levels of serum Cats and hs-CRP in ACSgroup were （0.45±0.06） nmol/L and （6.05± 3.25） mg/L, compared with before treatment （0.51± 0.03） nmol/L and （10.21± 5.03） mg/L, which were significantly decreased, there were statistically significant differences （P〈0.05）. CONCLUSION： Changes of hs-CRP, CatS level in ACS patients suggest that hs-CRP and CatS may play an important role in acute coronary syndrome, CatS may possibly act as a new biomarker of ACS. KEY WORDS Cathepsin S; Acute coronary syndrome; High sensitive creactive protein