| P63蛋白在宣威与非宣威地区非小细胞肺癌中表达的对比研究 |
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| 引用本文： | 刘君,李高峰,陈楠,彭俊,陈新隆,王平,毛新,宁显谷. P63蛋白在宣威与非宣威地区非小细胞肺癌中表达的对比研究[J]. 昆明医学院学报, 2014, 0(1): 37-41 |
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| 作者姓名： | 刘君 李高峰 陈楠 彭俊 陈新隆 王平 毛新 宁显谷 |
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| 作者单位： | 刘君(云南省第一人民医院，昆明理工大学附属昆华医院胸心血管外科，云南昆明 650032)； 李高峰 (昆明医科大学第三附属医院，云南省肿瘤医院胸外科，云南昆明 650118)； 陈楠 (昆明医科大学第三附属医院，云南省肿瘤医院胸外科，云南昆明 650118)； 彭俊(云南省第一人民医院，昆明理工大学附属昆华医院胸心血管外科，云南昆明 650032)；陈新隆(云南省第一人民医院，昆明理工大学附属昆华医院胸心血管外科，云南昆明 650032)；王平(云南省第一人民医院，昆明理工大学附属昆华医院胸心血管外科，云南昆明 650032)；毛新(云南省第一人民医院，昆明理工大学附属昆华医院胸心血管外科，云南昆明 650032)；宁显谷(云南省第一人民医院，昆明理工大学附属昆华医院胸心血管外科，云南昆明 650032)； |
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| 摘 要： | 目的：研究宣威与非宣威地区非小细胞肺癌P63蛋白的表达，探讨其与生物学行为的关系．方法免疫组织化学法．结果 P63在肺鳞癌组织中高表达；非小细胞肺癌中，P63的表达与患者的TNM分期、组织分化程度及淋巴结转移情况有关，与患者性别无关；P63在非小细胞肺癌中在相同病理类型、分期、组织分化、淋巴结转移情况及相同性别的阳性表达率，宣威组与非宣威组比较，差异无统计学意义（P＞0.05）．结论 P63的表达在宣威并无地区特异性，并不是宣威肺癌高发的原因.
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| 关 键 词： | 非小细胞肺癌 P63蛋白 免疫组化 |
Comparison of P63 Protein Expression in Non-small Cell Lung Cancer between Xuanwei and Other Regions |
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| LIU Jun,LI Gao-feng,CHEN Nan,PENG Jun,CHEN Xin-long,WANG Ping,MAO Xin,NING Xian-gu. Comparison of P63 Protein Expression in Non-small Cell Lung Cancer between Xuanwei and Other Regions[J]. Journal of Kunming Medical College, 2014, 0(1): 37-41 |
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| Authors: | LIU Jun LI Gao-feng CHEN Nan PENG Jun CHEN Xin-long WANG Ping MAO Xin NING Xian-gu |
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| Affiliation: | 1) Dept. of Thoracic and Cardiovascular Surgery, The First People＇s Hospital of Yunnan Province, The Affiliated KunHua Medical Hospital of Kunming University of Science and Technology, Kunming Yunnan 650032; 2 ) Dept. of Thoracic Surgery, The 3rd Affiliated Hospital of Kunming Medical University, Yunnan Provincial Tumor Hospital, Kunming Yunnan 650118, China) |
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| Abstract: | Objective The purpose of the study was to compare the P63 expression in non-small cell lung cancer （NSCLC） between Xuanwei and other regions, and to investigate the relationship of P63 expression and biological behavior. Methods Immunohistochemical method was used. Results The results indicated that the expression of P63 in lung squamous cell carcinoma was extraordinarily high. P63 was related to the TNM staging system,tissue differentiation degree and lymph node metastasis,but not related to gender. In NSCLC,there was no significant difference of the P63 positive expression rate in the same pathological types, staging, tissue differentiation degree, lymph node metastasis and gender between Xuanwei and other regions. It indicated that the expression of P63 was not the reason why it was high incidence of lung cancer in Xuanwei region. |
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| Keywords: | Non-small cell lung cancer P63 protein Immunohistochemistry |
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