Bipolar disorder and parental psychopathology |
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Authors: | Dan Sucksdorff Roshan Chudal Auli Suominen Elina Jokiranta Alan S Brown Andre Sourander |
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Institution: | 1. Department of Child Psychiatry, Faculty of Medicine, Research Centre for Child Psychiatry, Institute of Clinical Medicine, University of Turku, Lemmink?isenkatu 3/Teutori (3rd floor), 20014, Turku, Finland 2. Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, USA 3. Department of Epidemiology, Columbia University, Mailman School of Public Health, New York, USA 4. Department of Child Psychiatry, Turku University Hospital, Turku, Finland
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Abstract: | Purpose Few population-based studies have examined the association between parental psychopathology and bipolar disorder (BPD) in offspring. One limitation is lack of control for potential confounding by indicators of parental socio-economic status or maternal smoking during pregnancy. Furthermore, none of them included analyses restricted to parental diagnoses received prior to the birth of the offspring. Associations could not be affected by child-related factors affecting the parent in such analyses. This study explores associations between those parental psychiatric disorders diagnosed at any point of time as well as those diagnosed before offspring birth, and BPD in offspring. Methods In this nested case–control study, we identified 1,861 cases, age up to 25 years, 3,643 matched controls, and their parents from Finnish national registers. The associations were examined using conditional logistic regression, calculating odds ratios (OR) and adjusting for region of birth, parental age and education and mother’s smoking during pregnancy. Results Anytime diagnosed parental disorders associating with BPD in offspring (95 % confidence interval) were BPD OR (maternal) 5.2 (2.52–10.62); OR (paternal) 8.1 (3.77–17.26)], schizophrenia and related psychoses OR (maternal) 3.1 (1.69–5.84); OR (paternal) 4.5 (1.97–10.27)], other affective disorders OR (maternal) 3.0 (2.08–4.21); OR (paternal) 3.0 (1.97–4.47)] and maternal anxiety disorders OR 2.6 (1.08–6.42). Statistically significant associations were also found for parental schizophrenia and related psychoses, and other affective disorders, diagnosed before offspring birth. Conclusions BPD is associated with many parental psychiatric disorders, particularly BPD and schizophrenia and related psychoses. The associations must be partially due to child-independent factors. Covariate adjustments had only a minor impact on the associations. |
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