Peculiarities of oxidative stress in the plasma of patients with familial hypercholesterolemia |
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| Authors: | I. F. Chernyad'eva N. S. Lopata G. I. Muzya V. I. Kulikov E. I. Nasonov V. V. Kukharchk |
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| Affiliation: | (1) Department of Extracorporeal Methods of Treatment, Laboratory of Clinical Immunology, A. L. Myasnikov Institute of Clinical Cardiology, Russian Cardiology Research-and-Manufacturing Complex, Moscow;(2) Laboratory of Lipid Biochemistry, Research-and-Manufacturing Complex of Medical Biotechnology, Ministry of Health, Moscow |
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| Abstract: | Plasma level of lipid-standardized vitamin E is decreased, while the concentration of inflammatory transmitters C3a(desArg) and C5a(desArg) is elevated in heterozygous familial hypercholesterolemia caused by apoB,E-receptor deficiency. Leukocytes isolated from these patients exhibit enhanced spontaneous aggregation of superoxide anion generation and are resistant to activation with exogenous platelet activation factor (10−6 M). Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 2, pp. 213–216, February, 1998 |
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| Keywords: | familial hypercholesterolemia oxidative stress vitamin E anaphylatoxins platelet activation factor |
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