Post-exercise ketosis and the glycogen content of liver and muscle in rats on a high carbohydrate diet |
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Authors: | J. H. Adams J. H. Koeslag |
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Affiliation: | (1) Department of Physiology, University of Cape Town Medical School, 7925 Observatory, South Africa |
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Abstract: | Summary Post-exercise ketosis is known to be suppressed by physical training and by a high carbohydrate diet. As a result it has often been presumed, but not proven, that the development of post-exercise ketosis is closely related to the glycogen content of the liver. We therefore studied the effect of 1 h of treadmill running on the blood 3-hydroxybutyrate and liver and muscle glycogen concentrations of carbohydrate-loaded trained (n=72) and untrained rats (n=72). Resting liver and muscle glycogen levels were 25%–30% higher in the trained than in the untrained animals. The resting 3-hydroxybutyrate concentrations of both groups of rats were very low: <0.08 mmol·1−1. Exercise did not significantly influence the blood 3-hydroxybutyrate concentrations of trained rats, but caused a marked post-exercise ketosis (1.40±0.40 mmol·1−1 1 h after exercise) in the untrained animals, the time-course of which was the approximate inverse of the changes in liver glycogen concentration. Interpreting the results in the light of similar data obtained after a normal and low carbohydrate diet it has been concluded that trained animals probably owe their relative resistance to post-exercise ketosis to their higher liver glycogen concentrations as well as to greater peripheral stores of mobilizable carbohydrate. |
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Keywords: | Ketosis 3-hydroxybutyrate Exercise Diet Carbohydrate-loading Muscle glycogen Liver glycogen Muscle malate dehydrogenase |
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