| 止咳平喘糖浆中盐酸麻黄碱的HPLC测定 |
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| 引用本文： | 郭鑫慧,王粉,蔡俊安.止咳平喘糖浆中盐酸麻黄碱的HPLC测定[J].中国中医药信息杂志,2009,16(11):48-49. |
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| 作者姓名： | 郭鑫慧 王粉 蔡俊安 |
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| 作者单位： | 河南百年康鑫药业有限公司,河南,郸城,477150 |
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| 摘 要： | 目的采用HPLC法测定止咳平喘糖浆中盐酸麻黄碱的含量。方法采用外标一点法，Diamonsil ODS1 C18柱，乙腈-0．1％磷酸溶液（含0．1％三乙胺）（3：97）为流动相，流速为1．0mL／min，检测波长为205nm。结果盐酸麻黄碱在0．12～0．96μg范围内呈良好线性关系，回归方程为Y=109759X＋3792．8，r=0．9998，平均加样回收率为98．4％，RSD=0．87％（n=5）。结论本方法简便、准确，专属性强，测定结果重复性好，可用于止咳平喘糖浆中盐酸麻黄碱的定量分析。
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| 关 键 词： | 止咳平喘糖浆 盐酸麻黄碱 高效液相色谱法 |
Determination of Ephedrine Hydrochloride in Zhike Pingchuan Tangjiang by HPLC |
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| GUO Xin-hui,WANG Fen,CAI Jun-an.Determination of Ephedrine Hydrochloride in Zhike Pingchuan Tangjiang by HPLC[J].Chinese Journal of Information on Traditional Chinese Medicine,2009,16(11):48-49. |
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| Authors: | GUO Xin-hui WANG Fen CAI Jun-an |
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| Institution: | (Henan Bainian Kangxin Pharmaceutical CO., Ltd, Dancheng 477150, China) |
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| Abstract: | Objective To establish the method for detemining the content of ephedrine hydrochloride in Zhike Pingchuan Tangjiang by HPLC. Methods Diamonsil ODS1 C18 Column was used with acetonitrile- 0.1% phosphoric solution （with 0.1% triehylamine） （3 ： 97） as the mobile phase, the detection wavelength as 205 nm, and flow rate was 1.0 mL/min. Results The calibration curve was linear at the range of 0.12 - 0.96 μg for ephedrine hydrochloride and linear equation was Y= 109 759X＋3 792.8, r=0.999 8. The average recovery was 98.4% and RSD was 0.87% （n =5）. Conclusion This method was simple, accurate and proper, with good reproducibility. It can be used for quantitative analysis of ephedrine hydrochloride in Zhike Pingchuan Tangjiang. |
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| Keywords: | Zhike Pingchuan Tangjiang ephedrine hydrochloride HPLC |
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