| 雌性大鼠尿流动力学检查指标的年龄变化 |
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| 引用本文： | 胡卫锋,杜广辉,蔡丹,陈园,章慧平,陈忠,袁晓奕,杨为民,叶章群.雌性大鼠尿流动力学检查指标的年龄变化[J].临床泌尿外科杂志,2008,23(7):547-549. |
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| 作者姓名： | 胡卫锋 杜广辉 蔡丹 陈园 章慧平 陈忠 袁晓奕 杨为民 叶章群 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院泌尿外科,武汉,430030;武汉市中心医院泌尿外科;华中科技大学同济医学院附属同济医院泌尿外科,武汉,430030 |
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| 摘 要： | 目的:探讨不同年龄段雌性大鼠尿动力学指标的变化趋势.方法:取4组年龄分别为6、12、18和24个月的雌性成年大鼠,乌拉坦腹腔麻醉,尿道内置人2根3F自制测压导管,分别与尿动力学检查仪的压力传感器及微量注射泵连接,同时由肛门置入直肠测压气囊管与腹压传感器连接.应用尿动力学检查仪测定大鼠充盈期膀胱压力变化和并描记静态尿道压力图.结果:雌性大鼠膀胱漏尿点压、最大膀胱排尿压、腹压漏尿点压以及最大膀胱容量在各年龄组无明显差别(P＞0.05);而最大尿道压、最大尿道闭合压以及功能性尿道长度随着年龄增加而显著下降(P＜0.05),但在≥18个月的两组雌性大鼠中无明显差异.结论:老龄化对雌性大鼠静态尿道压力参数的变化起重要作用,提示年龄可能是尿道变化特别是压力性尿失禁的重要危险因素.
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| 关 键 词： | 雌性大鼠 尿流动力学 年龄 尿道 |
Aging Effect on Female Rat Urodynamic Parameters |
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| HU Weifeng,DU Guanghui,CAI Dan,CHEN Yuan,ZHANG Huiping,CHEN Zhong,YUAN Xiaoyi,YANG Wemin,YE Zhangqun.Aging Effect on Female Rat Urodynamic Parameters[J].Journal of Clinical Urology,2008,23(7):547-549. |
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| Authors: | HU Weifeng DU Guanghui CAI Dan CHEN Yuan ZHANG Huiping CHEN Zhong YUAN Xiaoyi YANG Wemin YE Zhangqun |
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| Institution: | 1Department of Urology;Tongji Hospital;Huazhong University of Science and Technology;Wuhan;430030;China |
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| Abstract: | Objective:To evaluate the tendency of aging effect on female rats urodynamic parameters.Methods:Four groups of adult Sprague-Dawley female rats at different age underwent anesthesia with urethane intraperitoneally.Two ureteral catheters(3F) were inducted into rat bladder per urethra,and then conducted urodynamic study.Filling cystometry and static urethral pressure profile were recorded.Results:No statistically significant difference between groups was observed in bladder leak point pressure(BLPP),maximum b... |
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| Keywords: | Female rat Urodynamics Age Urethra |
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