Arrhythmogenic effects of endothelin-1 under conditions of NO-synthase blockade with L-NAME in NMRI mice |
| |
| Authors: | Murashev A N Rzhevskii D I Korshunov V A Lobanov A V |
| |
| Affiliation: | (1) Laboratory of Biological Trials, Affiliated Division of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino |
| |
| Abstract: | Arrythmogenic effects of endothelin-1 were studied in NMRI mice under conditions of NO-synthase blockade with N -nitro-L-arginine methyl ester. Intravenous injection of endothelin-1 increased heart rate variability in awake mice. NO-synthase blockade potentiated the arrythmogenic effects of endothelin-1. In narcotized animals the arrythmogenic effect of endothelin-1 was not observed and was considerably weakened under conditions of NO-synthase blockade. Arrhythmia was paralleled by atrioventricular block and lengthening of the ST segment. |
| |
| Keywords: | endothelin-1 nitrogen oxide L-NAME mice arrhythmia |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
