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Resveratrol represses YKL-40 expression in human glioma U87 cells |
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| Authors: | Wei Zhang Koji Murao Xiang Zhang Kensuke Matsumoto Suwarni Diah Masaki Okada Keisuke Miyake Nobuyuki Kawai Zhou Fei Takashi Tamiya |
| Affiliation: | 1.Department of Neurosurgery,Xijing Hospital, The Fourth Military Medical University,Xi'an,P.R. China;2.Department of Neurological Surgery, Faculty of Medicine,Kagawa University,Kida-gun,Japan;3.Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine,Kagawa University,Kida-gun,Japan;4.Department of Pharmacology, Faculty of Medicine,Kagawa University,Kida-gun,Japan |
| Abstract: | BackgroundGlioblastoma multiforme (GBM) is the most malignant intracranial tumour that develops in both adults and children. Microarray gene analyses have confirmed that the human YKL-40 gene is one of the most over-expressed genes in these tumours but not in normal brain tissue. Clinical studies have shown that serum YKL-40 levels are positively correlated with tumour burden in addition to being an independent prognostic factor of a short relapse-free interval as well as short overall survival in patients with various cancers. Our previous study revealed that YKL-40 was closely correlated with the pathological grades of human primary astrocytomas and played a crucial role in glioma cell proliferation. Hence, YKL-40 could be an attractive target in the design of anti-cancer therapies. |
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