矮小儿童221例临床分析

目的对221例身高低于同龄及同性别正常儿童均值减2个标准差或第三百分位数以下儿童进行临床分析。方法统一询问病史、体格检查、各项辅助检查和治疗。结果221例矮小儿童中,生长激素缺乏症75例(33.9%),其中76%(57/75)有难产史,rhGH治疗效果显著;其中体质性生长延迟43例(19.5%)、家族性矮小42例(19%),74%(63/85)有家族史;其中甲状腺功能低下2 l例(9.5%),甲状腺素替代治疗效果满意。结论矮小儿童中以生长激素缺乏症、体质性生长延迟、家族性矮小等常见,开展产前诊断和新生儿筛查是必要的。

Clinical analysis of microsomia children

Objective To analyse the clinical characteristics of 221 microsomia children whose mean stature is lower than that of the same age and same sex 2SD or who is under the third percentage.Methods Uniform investigation was adopted for diseased history,physical examination,all kinds of laboratory tests and treatment.Results Among the 221 cases of the microsomia children,75 of them(36.6%) were growth hormone deficiency.Among the 75 cases of GHD,57 of them(76%) had abnormal birth.The treatmental effectiveness by rhGH was obviously;The number of constitutional growth delay children was 43 cases(19.5%),the number of familiar short stature children was 42 cases(19%),Among them,63 cases(74%)had family history;Among 221 microsomia children,2l of them(9.5%)were congenital hypothyroidism.The treatment with the substitution of thyroxine had a good result.Conclusion The growth hormone deficiency,constitutional growth delay and familiar short stature are the common types in the microsomia children.The measure to improve the situation is to qualify the circumnatal period,perform the pre-natal check-up.