Interleukin-6 levels are increased in temporal lobe epilepsy but not in extra-temporal lobe epilepsy |
| |
Authors: | Suvi Liimatainen Mahdi Fallah Elham Kharazmi Maria Peltola Jukka Peltola |
| |
Institution: | (1) Department of Neurology and Rehabilitation, Tampere University Hospital, P.O. Box 2000, 33521 Tampere, Finland;(2) Tampere School of Public Health, University of Tampere, 33014 Tampere, Finland |
| |
Abstract: | Previous studies have reported activation of inflammatory cytokines in seizures, but clinical characteristics of epilepsy
associated with cytokine activation have not been well established. In this study, serum levels of interleukin-6 (IL-6) and
interleukin-1 receptor antagonist (IL-1RA) were measured, and clinical characteristics of epilepsy were assessed in 86 well-evaluated
patients with refractory focal epilepsy and in 5 patients with controlled focal epilepsy. Epilepsy was evaluated based on
patient histories, electroclinical findings, and high-resolution brain MRI scans. Sixty-three healthy blood donors served
as controls. IL-6 concentrations were chronically increased in epilepsy patients (11%) compared with healthy controls (0%)
(P = 0.007). Increased levels of IL-6 were more prevalent in patients with temporal lobe epilepsy (TLE) compared to patients
with extra-TLE (P = 0.028). Also the mean and the median serum levels of IL-6 were higher in patients with TLE than in patients with extra-TLE
(P = 0.042). Concentrations of IL-1RA were not significantly different in patients compared with controls. Indicated by increased
levels of IL-6 in TLE, epilepsy type is important in determining chronic overproduction of cytokines in refractory focal epilepsy.
The results may reflect a chronic immunological process in the brain in patients with refractory epilepsy. |
| |
Keywords: | Refractory focal epilepsy Cytokines Epilepsy type |
本文献已被 SpringerLink 等数据库收录! |
|