脑灵素胶囊的急性毒性和长期毒性实验观察

目的　观察脑灵素胶囊在小鼠的急性毒性和大鼠的长期毒性。方法　急性毒性 :每次按 1.0 5 g kg次 - 1给小鼠灌胃脑灵素 ,每天 2次 ,共 7d ,观察小鼠的一般活动情况及死亡数 ;长期毒性 :按 1.75g kg给大鼠灌胃脑灵素 ,每天 1次 ,连续 4wk ,观察记录大鼠的一般情况及体重变化。第 4周处死动物 ,取血样测定肝、肾功能 ,并计算重要脏器系数 ,取肝、脑、心、肾组织进行病理学检查。结果　急性毒性实验 :1wk内小鼠活动正常 ,无一小鼠死亡。长期毒性实验 :在所给剂量和用药时间 ,脑灵素无明显的毒性反映 ,给药组的体重变化、肝肾功能测定与对照组比较无明显差异 ,病理学切片检查也未见明显病理形态学改变。结论　脑灵素对肝、脑、心、肾等重要器官无明显的毒副作用。

The experimental observation of Capsule NaoLingSu about acute toxicity and chronic tocicity

Objective To observe acute toxicity of Capsule Naolingsu in mice and chronic toxicity of Capsule Naolingsu in rats .Methods NaoLingSu(1050mg/kg) was gived to mice by gavage two times a day for seven days in acute toxicity observation, then to observe mice's action and mortality;NaoLingSu(1.75mg/kg)was gived to rats by gavage once a day for four weeks in chronic toxicity observation , then to observe rats' action and weight . And rats were executed to sample blood to test function of liver and kidney on the fourth week .At the same time ,modulus of important organs was calculated and system of liver ,brain,heart and kidney was sended to have a pathologic test.Results mice's action was normal and none of them died during a week in acute toxicity experiment; Naolingsu has no obvious toxic reaction at gived dosage and administered time in chronic toxicity experiment, namely, weight and function of liver and kidney in administered group had no evident difference in comparison with normal group .Pathologic section test also had no apparent change in pathologic morphology.Conclusions Naolingsu had no obvious toxicity on such important organs as liver ,brain ,heart, kidney and so on.