| 低剂量IL-2治疗自身免疫性疾病的研究进展 |
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| 引用本文： | 张小娟,苏丽丽,孙剑.低剂量IL-2治疗自身免疫性疾病的研究进展[J].免疫学杂志,2019(6):543-548. |
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| 作者姓名： | 张小娟 苏丽丽 孙剑 |
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| 作者单位： | 天津大学药学院 |
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| 基金项目： | 国家自然科学基金(81273308) |
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| 摘 要： | IL-2是由活化T细胞产生的白介素家族成员之一,可以通过与细胞表面的白介素2受体结合而刺激T细胞的增殖、发育和分化。不同种类的T细胞对IL-2的敏感性不同,调节性T细胞(regulatory T cell,Treg)对IL-2的敏感性高于其它细胞。所以,低剂量的IL-2可以在不影响效应T细胞(effector T cell,Teff)的情况下,选择性激活Treg信号通路,调节Treg的细胞水平和功能,增强免疫抑制反应,进行免疫调控。目前,低剂量IL-2(low-doses IL-2,LdIL-2)在一些自身免疫疾病治疗研究中得到广泛关注。本文就低剂量IL-2治疗自身免疫性疾病的研究进展作一简要论述。
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| 关 键 词： | 低剂量白介素2 调节T细胞 自身免疫疾病 |
The progress of low-dose IL-2 as a treatment for autoimmune diseases |
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| ZHANG Xiaojuan,SU Lili,SUN Jian.The progress of low-dose IL-2 as a treatment for autoimmune diseases[J].Immunological Journal,2019(6):543-548. |
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| Authors: | ZHANG Xiaojuan SU Lili SUN Jian |
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| Institution: | (School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China) |
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| Abstract: | IL-2, a member of interleukin family, is produced by activated T cells. IL-2 can stimulate the T cell proliferation, development, and differentiation after binding to the IL-2 receptor. The sensitivity to IL-2 varies in different types of T cells. Regulatory T cells(Treg) are more sensitive to IL-2 than other effector T cells do. Lowdoses of IL-2(LdIL-2) can activate the signal pathway of the Treg cell without affecting the effector T cells, and regulates the proliferation and function of the Treg cells, as well as enhances the immunosuppressive response. At present, significant insight has been made in the treatment of LdIL-2 for some autoimmune diseases. This article reviews the progress of LdIL-2 in the treatment of autoimmune diseases. |
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| Keywords: | Low-dose interleukin-2 Treg cell Autoimmune disease |
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