丁苯酞胶囊治疗急性缺血性脑卒中

目的：评价丁苯酞胶囊治疗急性缺血性脑卒中的疗效。方法：119例急性缺血性脑卒中病人被随机分为2组,基础治疗均为维生素C注射液2 g加入低分子右旋糖苷500 mL,iv,gtt,qd,治疗组加用丁苯酞软胶囊200 mg,po,qid,疗程20 d。在治疗前和治疗后11,21 d分别测查日常生活活动能力(ADL)及神经功能缺损积分。结果：治疗11 d及21 d后2组病人间的ADL评分差别有显著意义(P＜0．05或0．01)；2组病人间的神经功能缺损评分差别有显著意义(P＜0．05或0．01)。治疗组病人,治疗前与治疗11 d及治疗21 d后ADL评分差别有显著意义(P＜0．01)；神经功能缺损评分差别有显著意义(P＜0．01)。对照组病人,治疗前与治疗11d后ADL及神经功能缺损评分差别无显著意义(P＞0．05)；治疗21 d后评分差别有显著意义(P＜0．05)。治疗11d后2组病人间的疗效差别无显著意义(P＞0．05)；治疗21 d后2组病人间的疗效差别有显著意义(P＜0．05)。结论：丁苯酞胶囊治疗急性缺血性脑卒中疗效确切。

Evaluation of butylphthalide in treating acute ischemic stroke

AIM:To evaluate the effects of butylphthalide in treating acute ischemic stroke.METHODS: One hundred and nineteen patients with acute ischemic stroke were randomized divided into two groups,59 patients treated by butylphthalide and 60 patients as normal control group.All selected patients were undertaken activities of daily life(ADL)test and evaluation of nervous functional deficiency degree before treatment and at d 11 and d 21 after the treatment.RESULTS:At d 11 and d 21 after treatment,there was a significant differ- ence in ADL between treatment group and control group(P＜0.05 or 0.01);and also a significant difference in the nervous functional deficiency degree between the two groups(P＜0.05 or 0.01).There was significant dif- ference in ADL and nervous functional deficiency between before treatment and after 11-day or 21-day treatment (P＜0.01)in treatment group,respectively.There was no significant difference in the two parameters between before treatment and after 11-day treatment in the control group(P＞0.05),while there was significant differ- ence between pre-treatment and after 21-day treatment(P＜0.05).Concerning no significant difference between the two groups in ADL and nervous functional deficiency degree at d 11 after treatment(P＞0.05),there was significant difference in the two parameters at d 21 after treatment(P＜0.05).CONCLUSION:Butylphthalide is safe and effective in treating acute ischemic stroke.