妊娠期高血压疾病患者血清胱抑素C和尿微量白蛋白检测的临床意义

目的探讨妊娠期高血压疾病（HDCP）患者血清胱抑素C（Cys-C）和尿微量白蛋白（UmAlb）联合检测的临床价值。方法选择HDCP患者143例,其中,妊娠期高血压68例,轻度子痫前期43例,重度子痫前期32例。另选择同期在本院产前体检的30例正常孕妇作为对照组。分别采血及尿液检测血Cys-C、尿素氮（BUN）、肌酐（Scr）和UmAlb水平并进行比较分析。结果妊娠期高血压组、轻度子痫前期组、重度子痫前期组三组患者血清Cys-C及UmAlb水平均显著高于对照组（P均〈0.01）;妊娠期高血压组、轻度子痫前期组、重度子痫前期组三组间Cys-C和UmAlb水平比较,差异均有统计学意义（妊娠期高血压组〈轻度子痫前期组〈重度子痫前期组,P均〈0.01）。重度子痫前期组血BUN和Scr水平均明显高于对照组（P〈0.01）,而妊娠期高血压组、轻度子痫前期组血BUN、Scr水平与对照组比较,差异均无统计学意义（P均＆gt;0.05）。结论血清Cys-C和UmAlb均为反映HDCP患者早期肾功能损害的敏感指标,两者联合检测对HDCP早期肾损害的诊断有重要价值。

Clinical significance of detection of serum cystatin C combined with urinary microalbumin for patients with hypertensive disorder complicating pregnancy

Objective To explore the clinical value of detecting serum cystatin-C（Cys-C） combined with urine microalbumin（UmAlb） for patients with hypertensive disorder complicating pregnancy（HDCP）. Methods 143 patients with HDCP were selected, including pregnancy-induced hypertension of 68 cases, mild pre-eclampsia of 43 cases and severe-eclampsia of 32 cases. Moreover, 30 normal pregnant women were served as control group. The levels of serum Cys-C, blood urea nitrogen（BUN）, serum creatinine（Scr） and UmAlb were detected and compared. Results The levels of serum Cys-C and UmAlb in pregnancy-induced hypertension group, mild pre-eclampsia group and severe-eclampsia group were significantly higher than the control（P0.01）. There were significantly differences among pregnancy-induced hypertension group, mild pre-eclampsia group and severe-eclampsia group of levels of Cys-C and UmAlb（pregnancy-induced hypertension groupmild preeclampsia groupsevere-eclampsia group, P0.01）. The levels of BUN and Scr of severe-eclampsia group were significantly higher than the control（P0.01）, but they had no significant difference among pregnancyinduced hypertension group, mild pre-eclampsia group and control group（P0.05）. Conclusion Serum Cys-C and UmAlb are sensitive indicators to reflect early renal damage of HDCP patients. Detection of serum Cys-C combined with UmAlb in HDCP patients is helpful to early diagnosis of renal damage.