Prenatal corticosteroid in preventing respiratory distress syndrome |
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| Authors: | E Ho |
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| Affiliation: | 1. Department of Pharmacy, Children''s Mercy Kansas City, 2401 Gillham Road, Kansas City, MO 64108, USA;2. School of Medicine, University of Missouri-Kansas City, 2411 Holmes Street, Kansas City, MO 64108, USA;3. Division of Neonatology, Department of Pediatrics, Children''s Mercy Kansas City, 2401 Gillham Road, Kansas City, MO 64108, USA;4. Center for Infant Pulmonary Disorders, Children''s Mercy Kansas City, 2401 Gillham Road, Kansas City, MO 64108, USA;5. School of Medicine, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160, USA;1. Department of Neonatology, Kabul University of Medical Sciences, 3rd district, 1003, Kabul, Afghanistan;2. Department of Neonatology, French Medical Institute for Mothers and Children Hospital, 3rd district, 1003, Kabul, Afghanistan;3. Saints John''s Regional Medical Centre, United States;4. Department of Infectious Diseases. Kabul University of Medical Sciences, 3rd district, 1003, Kabul, Afghanistan |
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| Abstract: | Approximately 9% of labours occur before the 37th week of gestation. The contribution of prematurity to neonatal morbidity and mortality is great, accounting for about 80% of neonatal deaths not associated with mere abnormality. Among the complications of prematurity, respiratory distress syndrome (RDS) continues to dominate, accounting for about 25% of all neonatal deaths. Hence any therapy able to improve the viability of preterm babies would be of great benefit.One way in which a drug might influence morbidity and mortality at preterm delivery is the administration of prenatal corticosteroids to accelerate pulmonary surfactant production hence reducing the risk of RDS. This paper reviews some literature on research studies of surfactant production and the efficacy of prenatal administration of corticosteroids in preventing RDS. |
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