Unchanged expression of Epstein-Barr virus-determined nuclear antigen-1 in productive virus cycle |
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| Authors: | Z Nováková V Krchnák J Roubal |
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| Institution: | Department of Experimental Virology, Institute of Sera and Vaccines, Prague, Czechoslovakia. |
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| Abstract: | The level of the Epstein-Barr virus (EBV)-determined nuclear antigen (EBNA-1) encoded by the Bam HI-K fragment of EBV DNA remained unchanged in P3HR-1 cells after induction of the productive cycle of virus replication by sodium-n-butyrate and 12-o-tetradecanoylphorbol-13-acetate (TPA). This was shown by the same capacity of cell-free extracts from untreated and treated P3HR-1 cells to absorb anti-EBNA-1 antibody from a known human serum. |
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