p-MAPK、cyclinD1和p53蛋白在大肠癌中的表达及其相关性

目的：检测ｐ－ＭＡＰＫ、ｃｙｃｌｉｎＤ１和ｐ５３蛋白在大肠癌中的表达，并探讨其相关性。方法：免疫组织化学Ｓ－Ｐ法。结果：１４０例大肠癌中ｐ－ＭＡＰＫ、ｃｙｃｌｉｎＤ１和ｐ５３蛋白的阳性表达率分别为９２．９％（１３０／１４０）、８７．１％（１２２／１４０）和６６．４％（９３／１４０）；５０例相应癌旁肠粘膜中阳性表达率分别为４．０％（２／５０）、６．０％（３／５０）和２．０％（１／５０）。三者阳性表达

Expression of p-MAPK, cyclinD1 and p53 proteins and colorectal carcinoma

Purpose To detect the expression of p MAPK,cyclinD1 and p53 proteins in human colorectal carcinomas, and explore their correlation. Method Expressions of p MAPK, cyclinD1 and p53 was examined by S P immunohistochemistry in paraffin embedded tissue serial sections from 140 cases of colorectal carcinoma and 50 cases of the mucosa adjacent to cancerous tissue. Results Positive expression rates for p MAPK, cyclinD1 and p53 proteins in colorectal carcinoma were 92 9%(130/140),87 1%(122/140) and 66 4%(93/140), and in the mucosa adjacent to cancerous tissue were 4 0%(2/50),6 0%(3/50) and 2 0%(1/50), respectively. Positive expression rates and levels of p MAPK, cyclinD1 and p53 protein in carcinoma were significantly higher than those in the mucosa ( P <0 01). Significant correlation between the expression of p MAPK and cyclinD1 was found( P <0 01). There was no significant correlation between the expression of p MAPK, cyclinD1 and p53 proteion( P >0 05). Conclusion The results indicate that MAPK may play an important role in the pathogenesis of colorectal carcinoma.