mTOR信号传导通路及其相关药物与非小细胞肺癌

哺乳动物雷帕霉素靶蛋白(mTOR)处于细胞生长繁殖、细胞周期调控、生物合成、细胞迁移等信号通路调控的中心位置,因此在肿瘤以及肺癌的发生、发展,特别是在治疗和预后中具有重要的作用.mTOR磷酸化激活后,通过调控4EBP和P70S6K两条不同的下游通路,分别控制特定亚组mRNA的翻译,进而影响生物合成.对非小细胞肺癌来讲,mTOR能够加快细胞周期G1-S期的转换,促进细胞增殖.雷帕霉素、西罗莫司、依维莫司等mTOR信号通路的阻断药物在肺癌的治疗中显示出了希望.

Relation of mTOR signal pathway and related drugs with non-small cell lung cancer

Mammalian target of rapamycin (mTOR) is an important convergence point in many signal pathways,such as cell growth and reproduction,cell cycle regulation,biosynthesis,cell migration.It plays an important role in the occurrence and development of tumor and lung cancer,particularly in the treatment and prognosis.The phosphorylated mTOR controls mRNA translation of specific subgroups by regulating 4EBP and P70S6K downstream pathways,and then affects the biosynthesis.In the non-small cell lung cancer,mTOR can accelerate cell cycle G1-S phase transition,promote cell proliferation.The inhibitors of mTOR signal pathway like Rapamycin,Sirolimus,and Everolimus seem to be reasonable in the treatment of lung cancer.