Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease |
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| Authors: | I. Moroo T. Yamada H. Makino I. Tooyama P. L. McGeer E. G. McGeer K. Hirayama |
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| Affiliation: | (1) Department of Neurology, Chiba University School of Medicine, 1-8-1 Inohana, Chuo-ku, 260 Chiba, Japan;(2) Second Division of Internal Medicine, School of Medicine, Chiba University, Chiba, Japan;(3) Institute of Molecular Neurobiology, Shiga University of Medical Science, Otsu, Shiga, Japan;(4) Kinsmen Laboratory of Neurological Research, Department of Psychiatry, and the Neurodegenerative Diseases Centre, University of British Columbia, Vancouver, Canada |
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| Abstract: | Immunohistochemistry using both a newly developed polyclonal, and a commercially available monoclonal, anti-insulin receptor antibody was done on the midbrain from cases of idiopathic Parkinson's disease (PD), Alzheimer's disease, amyotrophic lateral sclerosis, vascular parkinsonism and non-neurological controls. Both antibodies gave indentical patterns of neuronal staining. The neurons of the oculomotor nucleus were immunopositive in all the brains. However, the neurons in the pars compacta of the substantia nigra, paranigral nucleus, parabrachial pigmental nucleus, tegmental pedunculopontine nucleus, supratrocheal nucleus, cuneiform nucleus, subcuneiform nucleus and lemniscus medialis, which were positive in other diseases and in non-neurological controls, were not stained by these antibodies in PD brains. These results suggest that, in PD, a dysfunction of the insulin/insulin receptor system may precede death of the dopaminergic neurons.The work in the Kinsmen Laboratory was supported by the MRC of Canada and the Parkinson Society of Canada |
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| Keywords: | Parkinson's disease Substantia nigra Insulin receptor Immunochemistry |
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