Successive emergence of Enterobacter aerogenes strains resistant to imipenem and colistin in a patient |
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Authors: | Thiolas Aurélie Bollet Claude La Scola Bernard Raoult Didier Pagès Jean-Marie |
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Affiliation: | Enveloppe Bactérienne, Perméabilité et Antibiotiques, EA2197, IFR48, Faculté de Médecine, 27 Blvd. Jean Moulin, 13385 Marseille Cedex 05, France. |
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Abstract: | Enterobacter aerogenes is an agent of hospital-acquired infection that exhibits a remarkable resistance to beta-lactam antibiotics during therapy. Five successive isolates of E. aerogenes infecting a patient and exhibiting a multiresistance phenotype to beta-lactam antibiotics and fluoroquinolones were investigated. Among these clinical strains, four presented resistant phenotypes during successive imipenem and colistin treatments. The involved resistance mechanisms exhibited by the successive isolates were associated with alterations of the outer membrane that caused a porin decrease and lipopolysaccharide modifications. |
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