卡托普利和依那普利对冠心病和高心病患者中性粒细胞氧自由基的影响

本文检测70例外周分离的中性粒细胞氧自由基变化。其中正常未服药对照者20例,冠心病患者21例(服用卡托普利者8例,服用依那普利者6例,未服药者7例);高血压性心脏病患者29例(服用卡托普利者12例,服用依那普利者6例,未服药者11例)。结果发现:冠心病患者、高血压性心脏病患者在服用卡托普利或服用依那普利后,其中性粒细胞化学发光峰值、积分均显著低于两者未服药组;而冠心病、高血压性心脏病患者服用卡托普利或依那普利组中性粒细胞化学发光与正常未服药对照组相比无差异。患者服用卡托普利与服用依那普利间各检测指标无差异。

Effects of Captopril and Enalapril on Polymorphonuclear Leukocyte Oxygen Free Radical in Cardiovascular Disease Patients

70 cases of oxygen free radical of seperated polymorphonuclear leukocyte(PMNL) of peripheral whole whool changes were detected in this study. Study objects including 20 cases of normal take-no-medicine control group,21 cases of coronary heart disease (CHD) patients(subdivided into 8 cases take Captopril,6 cases take Enalapril and 7 cases take-no medicine) and 29 cases of hypertensive heart disease(HHD) patients(subdivided into 12 cases take Captopril, 6 cases take Enalapril and 11 cases take-no medicine).The results showed that after taking Captopril and Enalapril,the PMNL chemiluminescence CL) peak value and intergral in CHD and HHD patients were significantly lower than that in patients take-no-medicine group;PMNL-CL parameters in CHD patients take Captopril and Enalapril, HHD patients take Captopril and Enalapril had no significant difference than that in normal control group; the PMNL-CL parameters in CHD patients take Captopril and Enalapril,HHD patients take Capropril and Enalapril had no significant difference.